1. Vitamin D Deficiency Contributes to the Reduction and Impaired Function of Naïve CD45RA+ Regulatory T Cell in Chronic Heart Failure
- Author
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Yan-hui, Ma, Yun-lan, Zhou, Chao-yan, Yue, Guang-hui, Zhang, Lin, Deng, Guo-hua, Xie, Wei-ping, Xu, and Li-song, Shen
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Male ,lcsh:Immunologic diseases. Allergy ,Article Subject ,Anti-Inflammatory Agents ,chemical and pharmacologic phenomena ,T-Lymphocytes, Regulatory ,Interferon-gamma ,Humans ,Lymphocyte Count ,Aged ,25-Hydroxyvitamin D 2 ,Heart Failure ,Inflammation ,Interleukin-17 ,hemic and immune systems ,Middle Aged ,Flow Cytometry ,Vitamin D Deficiency ,Interleukin-10 ,CD4 Antigens ,Leukocyte Common Antigens ,Th17 Cells ,Female ,lcsh:RC581-607 ,Research Article ,circulatory and respiratory physiology - Abstract
The effect of vitamin D pertinent to cardiovascular health on the heart itself is considered to shift toward an anti-inflammatory response in chronic heart failure (CHF); however, its underlying mechanism is not completely understood. In this study, we demonstrated that plasma 25(OH)D level, negatively associated with NT-ProBNP, correlated with the decreased Treg in CHF compared to the patients with other cardiovascular diseases and healthy and older donors. Naïve Treg cell (CD4(+)CD45RA(+)Foxp3(lo)T) subset, rather than whole Treg cells, contributes to the reduction of Treg in CHF. 1,25(OH)2D treatment maintained partial expression of CD45RA on CD4(+)T cell after αCD3/CD28 monoclonal antibodies activation and ameliorated the impaired CD4(+)CD45RA(+)T cell function from CHF patients through upregulating Foxp3 expression and IL-10 secretion in vitro. Low level of vitamin D receptor (VDR) was detected in CD4(+)CD45RA(+)T cell of CHF than control, while 1,25(OH)2D treatment increased the VDR expression to exert its immunosuppression on T cell. The results of this study might provide tangible evidence to our knowledge of the impact of vitamin D supplementation on naïve Tregs, which may offer new means of preventing and treating CHF.
- Published
- 2015
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