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5 results on '"Ghiglione, P."'

1. Early weight loss in amyotrophic lateral sclerosis: Outcome relevance and clinical correlates in a population-based cohort

Author

Moglia, C., Calvo, A., Grassano, M., Canosa, A., Manera, U., D'Ovidio, F., Bombaci, A., Bersano, E., Mazzini, L., Mora, G., Chio, A., Cammarosano, S., Vasta, R., Torrieri, M. C., Solero, L., Clerico, M., De Mercanti, S., Mauro, A., Pradotto, L., De Marchi, F., Sosso, L., Leotta, D., Appendino, L., Imperiale, D., Cavallo, R., Geda, C., Poglio, F., Santimaria, P., Massazza, U., Villani, A., Conti, R., Ruiz, L. C., Palermo, M., Vergnano, F., Rota, E., Penza, M. T., Aguggia, M., Meineri, P., Ghiglione, P., Launaro, N., Astegiano, G., and Corso, G.

Subjects
Male, medicine.medical_specialty, amyotrophic lateral sclerosis, dysphagia, body mass index, Logistic regression, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Weight loss, respiratory function, Internal medicine, medicine, Humans, Respiratory function, Amyotrophic lateral sclerosis, weight loss, 030304 developmental biology, Aged, 0303 health sciences, business.industry, medicine.disease, Dysphagia, Survival Analysis, Clinical trial, Psychiatry and Mental health, Cohort, Disease Progression, Surgery, Female, Neurology (clinical), medicine.symptom, business, Body mass index, 030217 neurology & neurosurgery
Abstract

ObjectivesTo assess the role of body mass index (BMI) and of the rate of weight loss as prognostic factors in amyotrophic lateral sclerosis (ALS) and to explore the clinical correlates of weight loss in the early phases of the disease.MethodsThe study cohort included all ALS patients in Piemonte/Valle d’Aosta in the 2007–2011 period. Overall survival and the probability of death/tracheostomy at 18 months (logistic regression model) were calculated.ResultsOf the 712 patients, 620 (87.1%) were included in the study. Patients ’ survival was related to the mean monthly percentage of weight loss at diagnosis (pConclusionsThe rate of weight loss from onset to diagnosis was found to be a strong and independent prognostic factor in ALS. Weight loss was mainly due to the reduction of nutritional intake related to dysphagia, but a subgroup of spinal onset patients without dysphagia at diagnosis had a severe weight loss and an outcome similar to bulbar patients. According to our findings, we recommend that in clinical trials patients should be stratified according to the presence of dysphagia at the time of enrolment and not by site of onset of symptoms.

Published
2019

2. A Multicentric Prospective Incidence Study of Guillain-Barré Syndrome in Italy. The ITANG Study

Author

Benedetti, M, Pugliatti, M, Dalessandro, R, BEGHI, ETTORE, Chiò, A, Logroscino, G, Filippini, G, Galeotti, F, Massari, M, Santuccio, C, Raschetti, R, Abruzzi, L, Agazzi, E, Agostoni, E, Ambrogio, L, Amidei, S, Arbasino, C, Argentiero, V, Arnaboldi, M, Baldini, D, Barki, R, Bassi, P, Basso, F, Belcastro, V, Bellotti, M, Bersano, E, Besana, R, Bettoni, L, Bezzi, G, Bianconi, C, Bondavalli, M, Bonometti, A, Borghi, AM, Borsato, C, Bortolotto, S, Bottacchi, EF, Bresolin, N, Bruno, S, Burlina, A, Cafasso, G, Callegarini, C, Calvo, A, Candeloro, E, Casano, A, Cattaneo, SI, Cavallo, R, Cheldi, A, Ciardo, G, Cirignotta, F, Clerici, AM, Clerici, R, Comi, G, Conti, R, Coppo, F, Covelli, V, Crespi, V, Currò Dossi, M, Curtò, NA, D'Adda, E, Dallocchio, C, D'Anna, S, De Massis, P, De Toni Franceschini, L, Di Vito, N, Didonè, G, Dileone, M, Donati, E, Dotta, M, Fazio, R, Federico, F, FERRARESE, CARLO, Ferrazzini, F, Ferrero, B, Filosto, M, Frasson, E, Fusina, S, Galbussera, A, Gastaldo, E, Geda, C, Ghiglione, P, Giometto, B, Gionco, M, Giorgetti, A, Giussani, G, Gobbin, F, Grampa, G, Granieri, E, Greco, G, Guidetti, D, Guidi, C, Guidotti, M, Gusmaroli, G, Imperiale, D, Internò, S, Jann, S, La Spina, I, Leo, A, Leone, M, Leoni, S, Leotta, D, Lerario, R, Liotta, G, Livrea, P, Luda di Cortemiglio, E, Maggio, B, Magni, E, Magnoni, A, Maistrelli, J, Manca, D, Mandrioli, J, Manera, U, Marcello, N, Marchi, P, Marchini, C, Marconi, S, Mattioli, M, Mauro, A, Mazzaglia, G, Medici, D, Meineri, P, Meola, G, Micaglio, G, Michelucci, R, Michieli, G, Micieli, G, Minardi, C, Moglia, C, Monaco, S, Montanari, E, Moretto, G, Munerati, V, Mura, G, Mussutto, V, Nascimbene, C, Neri, W, Nichelli, P, Nobile Orazio, E, Oddenino, E, Onorato, S, Padovani, A, Palermo, M, Papurello, DM, Passarella, B, Pavesi, G, Penza, MT, Perini, M, Perini, F, Perla, F, Perlotto, N, Perrone, P, Pignatta, P, Pisano, F, Poglio, F, Polo, A, Poloni, M, Porazzi, D, Pradotto, L, Previdi, P, Quatrale, R, Rasi, F, Ravasio, A, Ravetti, C, Repaci, M, Riccardi, T, Riguzzi, P, Rinaldi, R, Riva, M, Romeo, V, Romorini, A, Rosso, T, Rotondo, G, Sacquegna, T, Sanson, F, Santamato, V, Santoro, D, Sartori, V, Sasanelli, F, Savio, K, Serena, M, Silani, V, Silvestri, L, Simioni, V, Squintani, GM, Suardelli, M, Tartagla, L, Terenghi, F, Terlizzi, E, Terzano, M, Tesser, F, Testa, L, Ticca, A, Ticozzi, N, Tiriticco, M, Tola, MR, Tonietti, S, Trianni, G, Trojano, M, Trotta, F, Turatti, M, Ursino, E, Vanotti, A, Vercellino, M, Villani, A, Vitelli, E, Zambito Marsala, S, Zanette, G, Zarcone, D, Zimatore, G, Zoccolella, S., Benedetti, Md, Pugliatti, M, D'Alessandro, R, Beghi, E, Chiò, A, Logroscino, G, Filippini, G, Galeotti, F, Massari, M, Santuccio, C, Comi, Giancarlo, Raschetti, R, ITANG Study, Group, Giometto, B, Benedetti, M, Dalessandro, R, Abruzzi, L, Agazzi, E, Agostoni, E, Ambrogio, L, Amidei, S, Arbasino, C, Argentiero, V, Arnaboldi, M, Baldini, D, Barki, R, Bassi, P, Basso, F, Belcastro, V, Bellotti, M, Bersano, E, Besana, R, Bettoni, L, Bezzi, G, Bianconi, C, Bondavalli, M, Bonometti, A, Borghi, A, Borsato, C, Bortolotto, S, Bottacchi, E, Bresolin, N, Bruno, S, Burlina, A, Cafasso, G, Callegarini, C, Calvo, A, Candeloro, E, Casano, A, Cattaneo, S, Cavallo, R, Cheldi, A, Ciardo, G, Cirignotta, F, Clerici, A, Clerici, R, Comi, G, Conti, R, Coppo, F, Covelli, V, Crespi, V, Currò Dossi, M, Curtò, N, D'Adda, E, Dallocchio, C, D'Anna, S, De Massis, P, De Toni Franceschini, L, Di Vito, N, Didonè, G, Dileone, M, Donati, E, Dotta, M, Fazio, R, Federico, F, Ferrarese, C, Ferrazzini, F, Ferrero, B, Filosto, M, Frasson, E, Fusina, S, Galbussera, A, Gastaldo, E, Geda, C, Ghiglione, P, Gionco, M, Giorgetti, A, Giussani, G, Gobbin, F, Grampa, G, Granieri, E, Greco, G, Guidetti, D, Guidi, C, Guidotti, M, Gusmaroli, G, Imperiale, D, Internò, S, Jann, S, La Spina, I, Leo, A, Leone, M, Leoni, S, Leotta, D, Lerario, R, Liotta, G, Livrea, P, Luda di Cortemiglio, E, Maggio, B, Magni, E, Magnoni, A, Maistrelli, J, Manca, D, Mandrioli, J, Manera, U, Marcello, N, Marchi, P, Marchini, C, Marconi, S, Mattioli, M, Mauro, A, Mazzaglia, G, Medici, D, Meineri, P, Meola, G, Micaglio, G, Michelucci, R, Michieli, G, Micieli, G, Minardi, C, Moglia, C, Monaco, S, Montanari, E, Moretto, G, Munerati, V, Mura, G, Mussutto, V, Nascimbene, C, Neri, W, Nichelli, P, Nobile Orazio, E, Oddenino, E, Onorato, S, Padovani, A, Palermo, M, Papurello, D, Passarella, B, Pavesi, G, Penza, M, Perini, M, Perini, F, Perla, F, Perlotto, N, Perrone, P, Pignatta, P, Pisano, F, Poglio, F, Polo, A, Poloni, M, Porazzi, D, Pradotto, L, Previdi, P, Quatrale, R, Rasi, F, Ravasio, A, Ravetti, C, Repaci, M, Riccardi, T, Riguzzi, P, Rinaldi, R, Riva, M, Romeo, V, Romorini, A, Rosso, T, Rotondo, G, Sacquegna, T, Sanson, F, Santamato, V, Santoro, D, Sartori, V, Sasanelli, F, Savio, K, Serena, M, Silani, V, Silvestri, L, Simioni, V, Squintani, G, Suardelli, M, Tartagla, L, Terenghi, F, Terlizzi, E, Terzano, M, Tesser, F, Testa, L, Ticca, A, Ticozzi, N, Tiriticco, M, Tola, M, Tonietti, S, Trianni, G, Trojano, M, Trotta, F, Turatti, M, Ursino, E, Vanotti, A, Vercellino, M, Villani, A, Vitelli, E, Zambito Marsala, S, Zanette, G, Zarcone, D, Zimatore, G, and Zoccolella, S

Subjects
Adult, Male, Pediatrics, medicine.medical_specialty, Epidemiology, Population, Guillain-Barre Syndrome, Rate ratio, NO, Young Adult, Axonal and demyelinating GBS, Guillain-Barré syndrome, Incidence, Prospective study, Trend, Neurology (clinical), Aged, Aged, 80 and over, Female, Humans, Italy, Middle Aged, 80 and over, medicine, Young adult, education, Prospective cohort study, education.field_of_study, Guillain-Barre syndrome, business.industry, Medicine (all), Incidence (epidemiology), medicine.disease, Vaccination, Settore MED/26 - NEUROLOGIA, business, Human
Abstract

Background: To assess Guillain-Barré syndrome (GBS) incidence we relied on the Italian Network for the study of GBS (ITANG) established in 2010 in 7 Italian regions to analyse the association between influenza vaccination and GBS. Methods: All individuals aged ≥18 years, presenting with clinical manifestations that suggested GBS according to the universally accepted Asbury's diagnostic criteria (1990) were prospectively notified to a centralised database by ITANG neurologists over the period October 1, 2010-September 30, 2011. Through a telephone survey, 9 trained interviewers followed up the cases to diagnosis and then for 1 year since hospital discharge. Validation of case reporting was performed with the support of administrative data in 5 regions. Results: We found 365 cases fulfilling the definition for GBS or one of its variants over 19,846,068 population ≥18 years of age, yielding an annual incidence rate of 1.84 per 100,000 (95% CI 1.65-2.03), 2.30 (95% CI 1.99-2.60) in men and 1.41 (95% CI 1.18-1.64) in women. A highly significant peak of incidence was observed in February 2011 as compared to reference month (September 2011, rate ratio 3.3:1, p < 0.01). Conclusions: In Italy, GBS incidence was among the highest reported in Europe and higher than previously observed in Italian studies.

Published
2015

3. Physical activity and amyotrophic lateral sclerosis: A European population-based case-control study

Author

Pupillo, E, Messina, P, Giussani, G, Logroscino, G, Zoccolella, S, Chiò, A, Calvo, A, Corbo, M, Lunetta, C, Marin, B, Hardiman, O, Rooney, J, Stevic, Z, Bandettini Di Poggio, M, Filosto, M, Cotelli, M, Perini, M, Riva, N, Vitelli, E, Damiani, D, Beghi, E, Al Chalabi A, Chiò A, Hardiman O, Logroscino G, Ludolph A, Mitchell D, Preux PM, Swingler R, van den Berg L, Addison R, Alvisi E, Astegiano G, Bonito V, Bottacchi E, Buzzi P, Canosa A, Capozzo R, Caponnetto C, Cavallo R, Ceroni M, Chiveri L, Corti S, Couratier P, Delodovici L, Durelli L, Ferrarese C, Ferrero B, Fetoni V, Gallo S, Geda C, Ghiglione P, Gionco M, Guaita MC, Joyce G, Launaro N, Lynch C, Lorusso L, Maestri E, Magliola U, Marchet A, Mauro A, Mazzini L, Micheli A, Milicev M, Millul A, Montesano M, Padovani A, Palazzini E, Palermo M, Papurello D, Pastore I, Penza MT, Perrone P, Pisano F, Prelle A, Raineri M, Regio V, Rigamonti A, Sasanelli F, Secchi P, Smith J, Tavernelli F, Vergnano F, Villani A, Arbore G, Case N, Del Sordo N, Di Landro A, Leali N, Masini L, Matuonto V, Monticelli ML, Montini A, Palumbo M, Parati A, Pellegrino S, Sessa A, Severgnini E, Vertué G., TREMOLIZZO, LUCIO, Pupillo, E, Messina, P, Giussani, G, Logroscino, G, Zoccolella, S, Chiò, A, Calvo, A, Corbo, M, Lunetta, C, Marin, B, Hardiman, O, Rooney, J, Stevic, Z, Bandettini Di Poggio, M, Filosto, M, Cotelli, M, Perini, M, Riva, N, Tremolizzo, L, Vitelli, E, Damiani, D, Beghi, E, Al Chalabi, A, Ludolph, A, Mitchell, D, Preux, P, Swingler, R, van den Berg, L, Addison, R, Alvisi, E, Astegiano, G, Bonito, V, Bottacchi, E, Buzzi, P, Canosa, A, Capozzo, R, Caponnetto, C, Cavallo, R, Ceroni, M, Chiveri, L, Corti, S, Couratier, P, Delodovici, L, Durelli, L, Ferrarese, C, Ferrero, B, Fetoni, V, Gallo, S, Geda, C, Ghiglione, P, Gionco, M, Guaita, M, Joyce, G, Launaro, N, Lynch, C, Lorusso, L, Maestri, E, Magliola, U, Marchet, A, Mauro, A, Mazzini, L, Micheli, A, Milicev, M, Millul, A, Montesano, M, Padovani, A, Palazzini, E, Palermo, M, Papurello, D, Pastore, I, Penza, M, Perrone, P, Pisano, F, Prelle, A, Raineri, M, Regio, V, Rigamonti, A, Sasanelli, F, Secchi, P, Smith, J, Tavernelli, F, Vergnano, F, Villani, A, Arbore, G, Case, N, Del Sordo, N, Di Landro, A, Leali, N, Masini, L, Matuonto, V, Monticelli, M, Montini, A, Palumbo, M, Parati, A, Pellegrino, S, Sessa, A, Severgnini, E, and Vertué, G

Subjects
Adult, Aged, 80 and over, Male, MED/26 - NEUROLOGIA, Amyotrophic Lateral Sclerosis, Middle Aged, Motor Activity, Europe, Neurology, Case-Control Studies, Population Surveillance, Humans, Female, Neurology (clinical), Case-Control Studie, Exercise, Aged, Amyotrophic Lateral Sclerosi, Human
Abstract

Objective To assess whether physical activity is a risk factor for amyotrophic lateral sclerosis (ALS). Methods From February 2008 to April 2012, 652 patients with ALS from European population-based registries (France, Ireland, Italy, United Kingdom, Serbia) and 1,166 population controls (matched for age, sex, and residency) were assessed. Upon direct interview, data were collected on occupation and history of sport and leisure activities, physical activity, and accidental injuries. Physical exercise was defined as having spent time doing activities that caused an individual to breath hard at least once per month and was coded as none, job-related, and/or sport-related. Sport-related and work-related physical exercise were quantified using metabolic equivalents (METs). Risks were calculated using conditional logistic regression models (adjusting for age, country, trauma, and job-related physical activity) and expressed as odds ratios (ORs) and adjusted ORs (Adj ORs) with 95% confidence intervals (CIs). Results Overall physical activity was associated with reduced odds of having ALS (Adj OR = 0.65, 95% CI = 0.48-0.89) as were work-related physical activity (Adj OR = 0.56, 95% CI = 0.36-0.87) and organized sports (Adj OR = 0.49, 95% CI = 0.32-0.75). An inverse correlation was observed between ALS, the duration of physical activity (p = 0.0041), and the cumulative MET scores, which became significant for the highest exposure (Adj OR = 0.34, 95% CI = 0.21-0.54). An inverse correlation between ALS and sport was found in women but not in men, and in subjects with repeated traumatic events. Interpretation Physical activity is not a risk factor for ALS and may eventually be protective against the disease. © 2014 American Neurological Association

Published
2014

4. Repeated courses of granulocyte colony-stimulating factor in amyotrophic lateral sclerosis: clinical and biological results from a prospective multicenter study

Author

Chiò, A, Mora, G, La Bella, V, Caponnetto, C, Mancardi, G, Sabatelli, M, Siciliano, G, Silani, V, Corbo, M, Moglia, C, Calvo, A, Mutani, R, Rutella, S, Gualandi, F, Melazzini, M, Scimè, R, Petrini, M, Bondesan, P, Garbelli, S, Mantovani, S, Bendotti, C, Tarella, C, Ghiglione, P, Omede, P, Ulla, M, Mascolo, M, Carlesi, C, Tonali, Pa, Conte, A, Luigetti, M, Alimonti, D, Onida, F, Bossolasco, P, Lambertenghi Deliliers, G, and Valentino, F.

Subjects
Adult, Male, Questionnaires, blood/cerebrospinal fluid/drug therapy, Amyotrophic Lateral Sclerosis, Pilot Projects, Middle Aged, blood/cerebrospinal fluid, Disability Evaluation, Treatment Outcome, Granulocyte Colony-Stimulating Factor, Adult, Aged, Amyotrophic Lateral Sclerosis, blood/cerebrospinal fluid/drug therapy, Cytokines, blood/cerebrospinal fluid, Disability Evaluation, Female, Follow-Up Studies, Granulocyte Colony-Stimulating Factor, blood/cerebrospinal fluid/therapeutic use, Humans, Male, Middle Aged, Pilot Projects, Prospective Studies, Questionnaires, Treatment Outcome, Cytokines, Humans, Female, Prospective Studies, blood/cerebrospinal fluid/therapeutic use, Aged, Follow-Up Studies
Published
2011

5. Comorbidity between CIDP and diabetes mellitus: only a matter of chance?

Author

Chio', Adriano, Plano, F, Calvo, Andrea, Leone, M, Mutani, Roberto, Cocito, D, Terreni, Aa, Calvo, A, Ghiglione, P, Mutani, R, Sciolla, R, Durelli, Luca, Gaviani, P, Monaco, Francesco, Comitangelo, R, Sosso, L, Gionco, M, Nobili, M, Appendino, L, Buffa, C, Cavallo, R, Oddenino, E, Ferrari, G, Favero, M, Doriguzzi Bozzo, C, Santamaria, P, Massazza, U, Villani, A, Conti, R, Mora, G, Palermo, M, Vergnano, F, Aguggia, M, Penza, Mt, Fassio, F, Di Vito, N, Meineri, P, Seliak, D, Dutto, A, Dotta, M, Astegiano, G, Corso, G, and Bottacchi, E.

Subjects
Adult, Male, medicine.medical_specialty, Time Factors, Population, Chronic inflammatory demyelinating polyneuropathy, Comorbidity, Diabetes Complications, Age Distribution, Risk Factors, Internal medicine, Diabetes mellitus, Epidemiology, medicine, Diabetes Mellitus, Prevalence, Humans, Age of Onset, Sex Distribution, education, Aged, education.field_of_study, business.industry, Clinical course, Cerebrospinal Fluid Proteins, Middle Aged, medicine.disease, Confidence interval, Surgery, Causality, Early Diagnosis, Neurology, Italy, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, Disease Progression, Female, Neurology (clinical), Age of onset, business
Abstract

Background and purpose: It is well known that chronic inflammatory demyelinating polyneuropathy (CIDP) and diabetes mellitus (DM) are often associated, but it is not clear if these two disorders are patogenetically correlated. Methods: An epidemiological study on CIDP in two Italian regions (population 4 334 225) was performed, using multiple concurrent sources of cases. The presence of DM was assessed on basis of the data reported in the clinical records of each patient. Standardized morbidity ratio (SMR) was calculated, using as reference the prevalence of DM in northern Italy. Results: At the prevalence day 155 patients with CIDP resident in Piemonte and Valle d’Aosta were found. Of these, 14 were also affected by either type 1 or type 2 DM. The number of expected individuals with associated DM was 13.03, corresponding to a SMR of 1.07 [95% confidence intervals (CI), 0.58–1.80]. Patients with CIDP associated with DM had a higher level of CSF proteins and a longer delay from onset to diagnosis than patients without DM, but did not differ for age of onset, gender distribution, and type of clinical course. Conclusions: Our epidemiological findings do not support a pathogenetic correlation between DM and CIDP.

Published
2009

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