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Africa is a giant market with a population of Europe and Japan combined, and highly diversified with respect to culture, natural resources, economic development, and political regimes. Yet, the continent is largely ignored with respect to research on the multinational activities of U.S. firms. In this paper, we provide the first evidence regarding the operating characteristics of U.S. firms that operate in Africa. We find that firms with operations in Africa are larger, more diversified, and more profitable than a matched control sample of multinational firms. This paper also shows that technology firms, manufacturing firms, and mining firms dominate the rest of companies operating in Africa. Certain geographical regions in Africa also seem to attract more companies than others, with Southern Africa being the most preferred region, while Central Africa is the least preferred. Finally, when a multinational firm invests in a specific country in Africa, it tends to do so in several business sectors. [ABSTRACT FROM PUBLISHER]