1. Population prevalence of Down's syndrome in the United Kingdom.
- Author
-
Alexander, M., Ding, Y., Foskett, N., Petri, H., Wandel, C., and Khwaja, O.
- Subjects
DOWN syndrome ,AGE differences ,SEX differences (Biology) ,PUBLIC health ,LIFE expectancy ,ADULTS ,AGE distribution ,CONFIDENCE intervals ,DATABASES ,MEDICAL information storage & retrieval systems ,PRIMARY health care ,PROBABILITY theory ,SEX distribution ,SECONDARY analysis ,DATA analysis software ,DESCRIPTIVE statistics ,ODDS ratio - Abstract
Background Aim was to estimate the age and sex-stratified prevalence of Down's syndrome (DS) in the United Kingdom (UK) general population using a large primary care database. Method Data source was the Clinical Practice Research Datalink. We divided the number of individuals with a record of DS present on 01/07/2014 by the total number of individuals, and computed Wilson's confidence intervals. Prevalence by age and sex was represented using local linear smoothing plots. Results On July 1
st 2014, 1159 females and 1317 males with DS were present in the data, corresponding to a prevalence of 5.9 per 10 000 (95% CI: 5.5; 6.2) in females and 6.8 (6.5; 7.2) per 10 000 in males. Prevalence of DS was increased in individuals aged 40 to 55 years compared to adjacent age groups. Conclusions A relative peak prevalence of DS at age 40-55 years may be attributed to the combined effects of a rise in life expectancy and the still limited availability of selective abortion. [ABSTRACT FROM AUTHOR]- Published
- 2016
- Full Text
- View/download PDF