1. Avoidance memory requires CaMKII activity to persist after recall.
- Author
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Radiske, Andressa, Gonzalez, Maria Carolina, Rossato, Janine I., Apolinário, Gênedy, de Oliveira, João R., Bevilaqua, Lia R. M., and Cammarota, Martín
- Subjects
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LABORATORY rats , *PROTEIN kinases , *MEMORY , *ADULTS - Abstract
Avoidance memory is destabilized when recalled concurrently with conflicting information, and must undergo a hippocampus-dependent restabilization process called reconsolidation to persist. CaMKII is a serine/threonine protein kinase essential for memory processing; however, its possible involvement in avoidance memory reconsolidation has not yet been studied. Using pharmacological, electrophysiological and optogenetic tools, we found that in adult male Wistar rats hippocampal CaMKII is necessary to reconsolidate avoidance memory, but not to keep it stored while inactive, and that blocking reconsolidation via CaMKII inhibition erases learned avoidance responses. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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