1. Olfactory dysfunction and chronic cognitive impairment following SARS-CoV-2 infection in a sample of older adults from the Andes mountains of Argentina
- Author
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Zamponi, Hernan P., Juarez-Aguayso, Leonardo, Kukoc, Gabriela, Domínguez, María Eugenia, Pini, Belén, Padilla, Eduardo G., Calvó, María, Molina-Rangeon, Silvia Beatriz, Guerrero, Gonzalo, Figueredo-Aguiar, Mariana, Fumagalli, Emiliano, Yécora, Agustín, Brugha, Traolach S., Seshadri, Sudha, Snyder, Heather M., Erausquin, Gabriel A. de, and Gonzalez-Aleman, Gabriela
- Subjects
Psychiatry and Mental health ,Cellular and Molecular Neuroscience ,Developmental Neuroscience ,Epidemiology ,SARS-CoV-2 ,Health Policy ,ADULTOS MAYORES ,ANOSMIA PERSISTENTE ,COVID-19 ,Neurology (clinical) ,Geriatrics and Gerontology ,DETERIORO COGNITIVO ,DISFUNCION OLFATORIA - Abstract
Fil: Zamponi, Hernan P. Ministerio de Salud de Jujuy; Argentina Fil: Juarez-Aguayso, Leonardo. Ministerio de Salud de Jujuy; Argentina Fil: Kukoc, Gabriela. Ministerio de Salud de Jujuy; Argentina Fil: Domínguez, María Eugenia. Ministerio de Salud de Jujuy; Argentina Fil: Pini, Belén. Ministerio de Salud de Jujuy; Argentina Fil: Padilla, Eduardo G. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina Fil: Calvó, María. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina Fil: Molina-Rangeon, Silvia Beatriz. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina Fil: Guerrero, Gonzalo. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina Fil: Figueredo-Aguiar, Mariana. Fundación de lucha contra los trastornos neurológicos y psiquiátricos en minorías; Argentina Fil: Fumagalli, Emiliano. Universidad Nacional de Jujuy; Argentina Fil: Yécora, Agustín. Ministerio de Salud de Jujuy; Argentina Fil: Brugha, Traolach S. University of Leicester; Reino Unido Fil: Seshadri, Sudha. University of Texas Health Science Center at San Antonio; Estados Unidos Fil: Seshadri, Sudha. Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases; Estados Unidos Fil: Snyder, Heather M. Alzheimer’s Association; Argentina Fil: Erausquin, Gabriel A. de. Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases; Estados Unidos Fil: Erausquin, Gabriel A. de. University of Texas Health Science Center at San Antonio; Estados Unidos Fil: Gonzalez-Aleman, Gabriela. Pontificia Universidad Católica Argentina; Argentina Abstract: Background: COVID-19 has affected more than 150 million people. The causal coronavirus, SARS-CoV-2 has infected twice as many individuals who have remained asymptomatic. COVID-19 includes central nervous system (CNS) manifestations and may result in chronic neuropsychiatric sequelae. Risk factors for COVID-19 sequelae overlap with those for Alzheimer’s disease (AD), particularly older age and ApoE4 status. The Alzheimer’s Association Consortium on Chronic Neuropsychiatric Sequelae of SARS-CoV-2 infection (CNS SC2) established harmonized definitions, ascertainment and assessment methodologies to evaluate and longitudinally follow up cohorts of older adults with variable exposure to COVID-19. We present preliminary data from CNS SC2 in a prospective cohort of 234 older adult Amerindians from Argentina. Method: Participants are ≥ 60 years recruited from the health registry of the Province of Jujuy containing all SARS-CoV-2 testing data (regardless of clinical status and of the result of the testing). We randomly invite older adults stratified by testing status regardless of symptom severity, a minimum of 3 months after clinical recovery (maximum 6 months); refusal to participate is
- Published
- 2021