1. Does immediate breast reconstruction after mastectomy and neoadjuvant chemotherapy influence the outcome of patients with non-endocrine responsive breast cancer?
- Author
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Aurilio G, Bagnardi V, Graffeo R, Nolè F, Jy, Petit, Locatelli M, Martella S, Iera M, Rey P, Curigliano G, Rotmensz N, elisabetta munzone, Goldhirsch A, Aurilio, G, Bagnardi, V, Graffeo, R, Nolè, F, Petit, J, Locatelli, M, Martella, S, Iera, M, Rey, P, Curigliano, G, Rotmensz, N, Munzone, E, and Goldhirsch, A
- Subjects
Adult ,locoregional recurrence ,Prognosi ,Receptor, ErbB-2 ,Mammaplasty ,Breast Neoplasms ,Follow-Up Studie ,non-endocrine responsive patient ,Retrospective Studie ,Antineoplastic Combined Chemotherapy Protocols ,invasive breast cancer ,Humans ,Cyclophosphamide ,Mastectomy ,Aged ,Neoplasm Staging ,Retrospective Studies ,Antineoplastic Combined Chemotherapy Protocol ,Immediate breast reconstruction ,Carcinoma, Ductal, Breast ,Lymphatic Metastasi ,Middle Aged ,Prognosis ,Combined Modality Therapy ,Neoadjuvant Therapy ,Survival Rate ,Carcinoma, Lobular ,Methotrexate ,Chemotherapy, Adjuvant ,Lymphatic Metastasis ,Female ,Neoplasm Recurrence, Local ,Breast Neoplasm ,Human ,Follow-Up Studies - Abstract
Background/Aim: In breast cancer (BC) patients, breast surgery followed by immediate breast reconstruction (IBR) might favour recurrences and metastases due to extensive surgical manipulation. We retrospectively investigated whether IBR after mastectomy and neoadjuvant chemotherapy (NT) influenced the outcome in patients with early and locally advanced oestrogen receptor (ER)-negative BC. Patients and Methods: Between 1995 and 2006, 133 BC patients received NT followed by total mastectomy, 59 of whom underwent IBR. Patients receiving IBR (IBR group) were compared to patients who did not receive IBR (no-IBR group) over a prolonged median follow-up time (8.2 years). Results: Patients receiving IBR were on average younger than patients not receiving IBR (p
- Published
- 2014