1. Treatment of Post-Hypoxic Myoclonus using Pallidal Deep Brain Stimulation Placed Using Interventional MRI Methods
- Author
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Gao, Fay, Ostrem, Jill L, and Wang, Doris D
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Assistive Technology ,Clinical Research ,Rehabilitation ,Neurosciences ,Bioengineering ,Neurodegenerative ,Neurological ,Adult ,Deep Brain Stimulation ,Drowning ,Female ,Globus Pallidus ,Heart Arrest ,Humans ,Hypoxia ,Brain ,Implantable Neurostimulators ,Magnetic Resonance Imaging ,Myoclonus ,Radiology ,Interventional ,myoclonus ,GPi ,iMRI ,DBS ,Lance-Adams syndrome - Abstract
BackgroundPost-hypoxic myoclonus (PHM) is characterized by generalized myoclonus after hypoxic brain injury. Myoclonus is often functionally impairing and refractory to medical therapies. Deep brain stimulation (DBS) has been used to treat myoclonus-dystonia, but few cases of PHM have been described.Case reportA 33-year-old woman developed severe, refractory generalized myoclonus after cardiopulmonary arrest from drowning. We performed MRI-guided asleep bilateral pallidal DBS placement, resulting in improvement in action myoclonus at one year.DiscussionOur case contributes to growing evidence for DBS for PHM. Interventional MRI guided DBS technique can be used for safe and accurate lead placement.HighlightsWe report a case of a patient who developed post-hypoxic myoclonus after cardiopulmonary arrest from drowning, who later underwent deep brain stimulation to treat refractory myoclonus. This is the first case to describe asleep, interventional MRI-guided technique for implanting DBS leads in post-hypoxic myoclonus.
- Published
- 2020