1. A combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma
- Author
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Jian-lan Xie, Yanlin Zhang, Jianguo Zhang, Tingting Bian, Yuan-yuan Zheng, Yifei Liu, and Xiao-ge Zhou
- Subjects
Adult ,Male ,0301 basic medicine ,LMO2 ,Pathology ,medicine.medical_specialty ,Histology ,Adolescent ,CD38 ,Sensitivity and Specificity ,Pathology and Forensic Medicine ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,immune system diseases ,Proto-Oncogene Proteins ,hemic and lymphatic diseases ,lcsh:Pathology ,Biomarkers, Tumor ,Humans ,Medicine ,Child ,11q Aberration ,Adaptor Proteins, Signal Transducing ,Aged ,Membrane Glycoproteins ,business.industry ,Research ,Area under the curve ,Burkitt lymphoma ,General Medicine ,LIM Domain Proteins ,Middle Aged ,medicine.disease ,Immunohistochemistry ,ADP-ribosyl Cyclase 1 ,Lymphoma ,Cd38 expression ,030104 developmental biology ,Child, Preschool ,030220 oncology & carcinogenesis ,Female ,business ,lcsh:RB1-214 - Abstract
Background To evaluate the clinical utility of LIM Domain Only 2 (LMO2) negative and CD38 positive in diagnosis of Burkitt lymphoma (BL). Methods LMO2 and CD38 expression determined by immunohistochemistry in 75 BL, 12 High-grade B-cell lymphoma, NOS (HGBL,NOS) and 3 Burkitt-like lymphomas with the 11q aberration. Results The sensitivity and specificity of LMO2 negative for detecting BL were 98.67 and 100%, respectively; those of CD38 positive were 98.67 and 66.67%, respectively. The sensitivity and specificity of a combination of both for detecting BL were 97.33 and 100%, respectively. In our study, the combined LMO2 negative and CD38 positive results had a higher area under the curve than either LMO2 negative or CD38 positive alone. Conclusions A combination of LMO2 negative and CD38 positive is useful for the diagnosis of Burkitt lymphoma.
- Published
- 2019