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To systematically explore potential biomarkers which can predict disease severity in COVID-19 patients and prevent the occurrence or development of severe COVID-19, the levels of 440 factors were analyzed in patients categorized according to COVID-19 disease severity; including asymptomatic, mild, moderate, severe, convalescent and healthy control groups. Factor candidates were validated by ELISA and functional relevance was uncovered by bioinformatics analysis. To identify potential biomarkers of occurrence or development of COVID-19, patient sera from three different severity groups (moderate, severe, and critical) at three time points (admission, remission, and discharge) and the expression levels of candidate biomarkers were measured. Eleven differential factors associated with disease severity were pinpointed from 440 factors across 111 patients of differing disease severity. The dynamic changes of GDF15 reflect the progression of the disease, while the other differential factors include TRAIL R1, IGFBP-1, IGFBP-4, VCAM-1, sFRP-3, FABP2, Transferrin, GDF15, IL-1F7, IL-5Rα, and CD200. Elevation of white blood cell count, neutrophil count, neutrophil-lymphocyte ratio (NLR), Alanine aminotransferase and Aspartate aminotransferase, low lymphocyte and eosinophil counts in the severe group were associated with the severity of COVID-19. GDF15 levels were observed to be associated with the severity of COVID-19 and the dynamic change of GDF15 levels was closely associated with the COVID-19 disease progression. Therefore, GDF15 might serve as an indicator of disease severity in COVID-19 patients.

To investigate the efficacy of endolymphatic sac surgery for Meniere's disease, and compare the effects of endolymphatic sac decompression with endolymphatic-mastoid shunting.Twelve patients(13 ears) undergoing endolymphatic-mastoid shunting and eleven patients (11 ears) undergoing endolymphatic sac decompression were retrospectively compared for hearing results and vertigo controlled rates. All of them have been followed up for more than two years after surgery.According to Chinese Meniere's disease diagnosis and curative effect standard evaluation criteria published in 2006, for vertigo symptom of endolymphatic mastoid shunting group, 9 cases (69.2%) achieved grade A(completely controlled), 4 cases (30.8%) achieved grade B (fundamentally controlled). There were 8 cases (72.7%) with grade A, 2 cases (18.2%) with grade B and one case (9%) with grade C among 11 patients who received endolymphatic sac decompression. There was not statistically significant differences in postoperative speech pure tone average and vertigo controlled rate between the two groups.Endolymphatic sac decompression and endolymphatic-mastoid shunting are effective management with less complication for intractable Meniere's disease. Particularly, the vertigo symptoms were controlled significantly. Patients with Meniere's disease in advanced clinical stages may also be relieved.

To study the feasibility and clinical values of occupational noise-induced hearing loss measured, evaluated and diagnosed with transient evoked otoacoustic emissions (TEOAE).Pure tone threshold and TEOAE were performed in 11 (22 ears) young adults with normal hearing of control group and 90 (180 ears) noise exposure workers of test group. According to length of noise exposure time, test group was disparted to test 1,2,3 groups. Stimulated tone of TEOAE is non-linearity click of 80 dB SPL.In test group and test 1,2,3 group against control, pure tone threshold in all frequency increased significantly, and correlation, strength and SNR of TEOAE in overall and every frequency declined significantly (P0.05 or P0.01). To observe test 1,2,3 group, It was found that pure tone threshold in all frequency increased and correlation, strength and SNR of TEOAE in overall and every frequency declined, when length of noise exposure time is increased. In 2.50-3.50 and 3.50-4.50 kHz, measuring values of TEOAE declined most significantly.Occupational noise-induced hearing loss can been measured and diagnosed significantly with TEOAE. The best observed contents is correlation, strength and SNR of TEOAE in overall and every part frequency. The best sensitivity observed frequency parts of TEOAE is 2.50-3.50 and 3.50-4.50 kHz.

To study the role of platelet activating factor (PAF) in the pathogenesis of secretory otitis media (SOM).The content of PAF in blood plasma and middle ear effusion(MEE) were measured in 56(68years) patients with secretory otitis media and in 40 normal subjects respectively by RP-HPLC.The concentration of PAF in MEE was remarkably higher than those in blood plasma (P0.01). The concentration of PAF in blood plasma in the SOM group was higher than those in the normal control group(P0.05). The concentration of PAF of MEE in the mucous fluid group was higher than those in the serous fluid group(P0.01).PAF might be an important mediator in MEE of SOM, it might be closely related to the persistence of SOM, and might play an important role in the pathogenesis of SOM.

To study the clinical characteristics and outline of surgery for carotid body tumor and glomus jugular tumor.Incisions of anterior border of sterno-mastoid muscle was made for simple carotid body tumor. A big S shape incisions and infratemporal fossa approach were employed which exposure the jugular foramen and apex of petrous for glomus jugular tumor or suffered carotid body tumor and glomus jugular tumor simultaneously in same side.Five cases of carotid body tumor were removed thoroughly and the internal carotid artery were intact reserved. In 5 cases of glomus jugular tumor 3 cases were removed thoroughly, other 2 cases of glomus jugular tumor were palliative operation, the remnant tumor have not increased in size after 1 to 3 years follow up.Chemodectoma have some genetic characteristic. Surgical intervention is the cardinal method of treatment.