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3 results on '"Xudan Yang"'

1. Metanephric stromal tumor in an adult with PDGFRA mutation: a case report

Author

Sanjun Guo, Huan Qian, Hong Zhu, Yue Yang, Xudan Yang, and Huajun Sun

Subjects
Metanephric stromal tumor, Adult, BRAF V600E mutation, PDGFRA mutation, Small diameter tumor, Pathology, RB1-214
Abstract

Abstract Background Metanephric stromal tumors (MST) are rare benign renal tumors that mainly occur in infants and children. Approximately 72% of MST in children have the B-Raf proto-oncogene serine/threonine kinase (BRAF) V600E mutation. To date, only five cases of adult MSTs have been reported and no clear genetic alterations have been found. Case presentation We report a case of MST in a 45-year-old woman who complained of left lower back pain for a week, accompanied by hypertension (150/79 mmHg). Magnetic resonance imaging (MRI) showed an abnormally enhanced nodule (1.1 cm in the middle of the left kidney), which was histopathologically consistent with an MST. The BRAF V600E mutation was not detected in tumor cells using PCR and next-generation sequencing (NGS). However, a platelet-derived growth factor receptor alpha (PDGFRA) mutation was detected in this case using NGS. The patient showed no recurrence or metastasis nine months after partial nephrectomy, and her blood pressure was consistently normal. Conclusion This is the first report of alterations in PDGFRA in MSTs. This result advances our knowledge of genetic variations in adult MSTs, which may have different gene alterations from MSTs in children.

Published
2023
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2. Agenesis of the dorsal pancreas presenting with diabetic ketoacidosis – a case report and literature review

Author

Xudan Yang, Jun Mo, Tian Yang, and Luping Wang

Subjects
Adult, Male, medicine.medical_specialty, Abdominal pain, Diabetic ketoacidosis, Endocrinology, Diabetes and Metabolism, Case Report, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Gastroenterology, Agenesis of the dorsal pancreas, Congenital Abnormalities, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Glucose Metabolism Disorder, Internal medicine, C-peptide release test, medicine, Humans, Pancreas, lcsh:RC648-665, business.industry, Metabolic acidosis, General Medicine, medicine.disease, Prognosis, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Ketonuria, Pancreatitis, medicine.symptom, business, 030217 neurology & neurosurgery
Abstract

Background Agenesis of the dorsal pancreas (ADP) is clinically rare, and it is usually accompanied by abdominal pain. Various disorders of glucose metabolism associating with ADP have been reported, but there are only two studies reporting a correlation between ADP and DKA in English literature. Case presentation We present a case of a patient with ADP accompanied by abdominal pain and diabetic ketoacidosis as the initial clinical presentation. A 30-year-old man presented with a 3-month history of recurrent onset of persistent mild epigastric pain, which worsen when eating. Laboratory tests revealed metabolic acidosis, hyperglycemia, and ketonuria. Phase contrast CT and MRCP showed the absence of the body and tail of the pancreas, as well as the dorsal pancreatic duct. The C-peptide release test indicated β-cell dysfunction. A combination therapy of insulin, pancreatic enzyme supplements, and mosapride citrate were administrated and the pain gradually resolved. Conclusions As glucose metabolism disorders can vary across different individuals, we advise clinicians to consider the diagnosis of ADP for a patient who presents with a glucose metabolism disorder accompanied by abdominal pain, pancreatitis or steatorrhea.

Published
2019

3. Chemokine CXCL14 is associated with prognosis in patients with colorectal carcinoma after curative resection

Author

Canhua Huang, Dandan Dong, Yunlong Lei, Ke Xie, Fanghua Li, Lin Cheng, Quek Choon Lau, Rui Liu, Xudan Yang, Edouard C. Nice, Jun Zeng, and Longfei Deng

Subjects
Adult, Male, Oncology, medicine.medical_specialty, Disease-free survival, Colorectal cancer, Blotting, Western, lcsh:Medicine, General Biochemistry, Genetics and Molecular Biology, Thyroid carcinoma, Breast cancer, Cell Line, Tumor, Internal medicine, medicine, Adjuvant therapy, Humans, Overall survival, MTT assay, Cloning, Molecular, CXCL14, Aged, DNA Primers, Aged, 80 and over, Medicine(all), Base Sequence, Biochemistry, Genetics and Molecular Biology(all), Matrigel Invasion Assay, business.industry, Research, lcsh:R, General Medicine, Middle Aged, Prognosis, medicine.disease, Immunohistochemistry, Up-Regulation, Colorectal carcinoma, Female, Neoplasm Recurrence, Local, Colorectal Neoplasms, business, Chemokines, CXC
Abstract

Background The chemokine CXCL14 has been reported to play an important role in the progression of many malignancies such as breast cancer and papillary thyroid carcinoma, but the role of CXCL14 in colorectal carcinoma (CRC) remains to be established. The purpose of this study was to investigate the expression pattern and significance of CXCL14 in CRC progression. Method 265 colorectal carcinoma specimens and 129 matched adjacent normal colorectal mucosa specimens were collected. Expression of CXCL14 in clinical samples was examined by immunostaining. The effect of CXCL14 on colorectal carcinoma cell proliferation was measured by MTT assay, BrdU incorporation assay and colony formation assay. The impact of CXCL14 on migration and invasion of colorectal carcinoma cells was determined by transwell assay and Matrigel invasion assay, respectively. Results CXCL14 expression was significantly up-regulated in tumor tissues compared with adjacent nontumorous mucosa tissues (P P = 0.024). Elevated CXCL14 expression in tumor specimens (n = 135) from stage III/IV patients correlated with worse overall survival (risk ratio, 3.087; 95% CI, 1.866-5.107; P Conclusion Taken together, CXCL14 might be a potential novel prognostic factor to predict the disease recurrence and overall survival and could be a potential target of postoperative adjuvant therapy in CRC patients.

Published
2013

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