1. Transcranial direct current stimulation reduces seizure frequency in patients with refractory focal epilepsy: A randomized, double-blind, sham-controlled, and three-arm parallel multicenter study
- Author
-
Hongmei Wang, Ye Wang, Tingting Yu, Fang Fang, Yiran Duan, Na Li, Zhaoyang Huang, Jingjing Fan, Jiaqi Han, Yue Wang, Cuiping Xu, Kun Yang, Qiaoyi Du, Qing Xue, Qun Wang, Zhang Zhang, Yulian Niu, Na Xu, Ting Li, Qilin Zhou, Xin Zhao, Ruihua Zhang, Xuan Zhao, Yuping Wang, Xiaona Dai, Xiao Liu, Changhong Ren, Chunhong Chen, Yicong Lin, Dongju Yang, Qinlan Xu, Liping Li, Jishui Zhang, Jing Li, Chunyan Liu, Huini Xu, Yi Zhang, and Qihui Zhou
- Subjects
Adult ,Male ,Drug Resistant Epilepsy ,medicine.medical_treatment ,Biophysics ,Stimulation ,Transcranial Direct Current Stimulation ,050105 experimental psychology ,lcsh:RC321-571 ,Double blind ,Refractory focal epilepsy ,03 medical and health sciences ,Epilepsy ,0302 clinical medicine ,Refractory ,Humans ,Medicine ,0501 psychology and cognitive sciences ,In patient ,lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry ,Interval between sessions ,Transcranial direct-current stimulation ,business.industry ,General Neuroscience ,05 social sciences ,Middle Aged ,medicine.disease ,Transcranial direct current stimulation (tDCS) ,Treatment Outcome ,Multicenter study ,Anesthesia ,Female ,Epilepsies, Partial ,Neurology (clinical) ,Analysis of variance ,Repeated sessions ,business ,030217 neurology & neurosurgery - Abstract
Background Transcranial direct current stimulation (tDCS) has been explored in epilepsy with limited samples, varied parameters, and inconclusive results. We aimed to study the efficacy of tDCS for patients with refractory focal epilepsy. Method We conducted a randomized, double-blind, sham-controlled, and three-arm (Group 1 (sham), Group 2 (20-min), and Group 3 (2 × 20-min)) tDCS parallel multicenter study. The primary outcome measurement was seizure frequencies (SFs). The study consisted of 28-days baseline, 14-days treatment, and 56-days follow-up. The cathode was placed over the epileptogenic focus, and the current intensity was 2 mA. The generalized estimating equations model, one-way analysis of variance, chi-square and Kruskal-Wallis test were used for analysis. Results Of the 82 enrolled patients, 70 patients were included for final analysis (Group 1, n = 21; Group 2, n = 24; and Group 3, n = 25). There was a significant reduction in SFs for both active tDCS groups compared with the sham group. Patients in Group 2 showed a significantly 50.73–21.91% greater reduction in SFs that lasted for 4 weeks (p = 0.008–0.060). Patients in Group 3 showed a significantly 63.19–49.79% greater reduction in SFs compared with the sham group that lasted for 5 weeks (p = 0.011–0.045). Patients in Group 3 had a 64.98–66.32% greater reduction in SFs at W9–W10, when compared with Group 2 (p = 0.021–0.022). Conclusion Fourteen consecutive days tDCS significantly decreased SFs in patients with refractory focal epilepsy, with 2 × 20-min daily stimulation protocol being superior to 20-min daily stimulation protocol.
- Published
- 2020