1. Susceptible gene single nucleotide polymorphism and hemorrhage risk in patients with brain arteriovenous malformation
- Author
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Tiewei Qi, Xue-song Li, Feng Liang, Shao-lei Guo, Zhengsong Huang, and Nan Jiang
- Subjects
Adult ,Intracranial Arteriovenous Malformations ,Male ,medicine.medical_specialty ,Adolescent ,Genotype ,Single-nucleotide polymorphism ,Protein Serine-Threonine Kinases ,Polymorphism, Single Nucleotide ,Gastroenterology ,Transforming Growth Factor beta1 ,Young Adult ,chemistry.chemical_compound ,Gene Frequency ,Physiology (medical) ,Internal medicine ,Humans ,Medicine ,Genetic Predisposition to Disease ,Genetic Testing ,Risk factor ,Allele ,Allele frequency ,Aged ,Genetics ,Intracerebral hemorrhage ,business.industry ,Interleukin-17 ,Receptor, Transforming Growth Factor-beta Type II ,Arteriovenous malformation ,General Medicine ,Middle Aged ,medicine.disease ,Neurology ,chemistry ,Female ,Surgery ,Neurology (clinical) ,business ,Intracranial Hemorrhages ,Receptors, Transforming Growth Factor beta ,Cytosine - Abstract
The relationship between single nucleotide polymorphism (SNP) of interleukin-17 (IL-17A), transforming growth factor β (TGF-β), as well as its receptor (TGFR-β2) and susceptibility to intracerebral hemorrhage in patients with brain arteriovenous malformation (BAVM) was investigated in the present study. A total of 53 patients with BAVM and 120 healthy controls were recruited, all of whom were Han Chinese from South China. There were no statistically significant differences in the IL-17A-197 guanine/adenine (G/A) or TGF-β1-509 cytosine/thymine (C/T) genotypes or gene frequencies between BAVM patients and controls (p>0.05), but the gene frequency of the TGFR-β2-875 A/G genotype in patients with BAVM was significantly higher (p
- Published
- 2011