1. Relationship Between Visceral Metastases and Survival in Patients with Metastasis‐related Spinal Cord Compression
- Author
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Deng‐xing Lun, Guochuan Zhang, Xiong-Gang Yang, Yu‐dong Ji, Qing‐shan Zhuang, Yong‐cheng Hu, Xiuchun Yu, and Xiao‐dong Wang
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adolescent ,Databases, Factual ,Metastasis‐related spinal cord compression ,Digestive System Neoplasms ,Karnofsky performance status ,Prognostic factors ,Gastroenterology ,Metastasis ,Young Adult ,Primary tumor ,03 medical and health sciences ,0302 clinical medicine ,lcsh:Orthopedic surgery ,Spinal cord compression ,Internal medicine ,medicine ,Humans ,Overall survival ,Orthopedics and Sports Medicine ,In patient ,Aged ,Retrospective Studies ,Aged, 80 and over ,030222 orthopedics ,Clinical Article ,Spinal Neoplasms ,Karnofsky Performance Status ,business.industry ,Medical record ,Middle Aged ,Prognosis ,medicine.disease ,Survival Analysis ,Cancer registry ,lcsh:RD701-811 ,Cohort ,Clinical Articles ,Female ,Surgery ,business ,Spinal Cord Compression ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
Objective To investigate whether visceral metastases have a significant impact on survival in patients with metastasis‐related spinal cord compression (MSCC), and to determine the difference in prognosis between patients with and without visceral metastases. Methods Three institutional databases were searched to identify all patients who had undergone spinal surgery for spinal metastases between March 2002 and June 2010. Data on patient characteristics including pre‐ and post‐operative medical conditions, were collected from medical records or by telephone follow‐up. Survival data were obtained either from medical records or by searching a governmental cancer registry. Results The mean age of study patients was 59.6 ± 10.5 years (range, 18–84 years), of whom 102 were male and 67 female. The median and mean postoperative survival times were 7.0 ± 0.5 (95% CI 6.0–8.0) months and 12.6 ± 1.2 (95% CI 10.1–15.0) months, respectively, in all patients, being 5.0 ± 0.5 (95% CI 4.0–6.0) months and 10.8 ± 2.4 (95% CI 6.1–15.5) months, respectively, for patients with visceral metastases and 7.0 ± 0.8 (95% CI 5.4–8.6) months and 13.0 ± 1.4 (95%CI 10.3–15.6) months, respectively, for patients without visceral metastases (P = 0.87). These survival times did not differ significantly between groups. Multivariate Cox proportional hazard regressions showed that visceral metastases had no statistically significant association with survival (P = 0.277), whereas rate of growth of primary tumor (P = 0.003), preoperative Karnofsky performance status (KPS) (P
- Published
- 2019