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Your search keyword '"Ouwerkerk J"' showing total 3 results
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3 results on '"Ouwerkerk J"'

1. Combination Chemotherapy in Advanced Adrenocortical Carcinoma

Author

Fassnacht, M., Terzolo, M., Allolio, B., Baudin, E., Haak, H., Berruti, A., Welin, S., Schade Brittinger, C., Lacroix, A., Jarzab, B., Sorbye, H., Torpy, D. J., Stepan, V., Schteingart, D. E., Arlt, W., Kroiss, M., Leboulleux, S., Sperone, P., Sundin, A., Hermsen, I., Hahner, S., Willenberg, H. S., Tabarin, A., Quinkler, M., De La Fouchardiere, C., Schlumberger, M., Mantero, F., Weismann, D., Beuschlein, F., Gelderblom, H., Wilmink, H., Sender, M., Edgerly, M., Kenn, W., Fojo, T., Muller, H. H., Skogseid, B., Haaf, M., Johanssen, S., Koschker, A. C., Laubner, K., Sbiera, S., Schiemann, J., Wortmann, S., Haase, M., Schott, M., Möhlig, M., Zopf, K., Reisch, N., Betz, M., Reincke, M., Isermann, B., Bornstein, S., Fottner, C., Bose, A., Petersenn, S., Leitolf, H., Klose, S., Wolf, H., Chougnet, C., More, J., Nunes, M. L., Droz, J. P., Nicolli, P., Chabre, O., Clergeot, A., Schillo, F., Penfornis, A., Do Cao, C., Goldwasser, F., Rodien, P., Ferrero, A., Perotti, P., Cicala Mv, Anna P., Della Casa, S., Mannelli, M., Piccini, V., Dercksen, M. W., Romijn, J. A., Ouwerkerk, J., Devries, J. H., Eriksson, B., Janson, E. T., Granberg, D., Oberg, K., Ahlman, H., Garkavij, M., Wall, N., Falkmer, U., Hammer, G., Olney, H. J., Bourdeau, I., Bourque, L., Szpak Ulczok, S., Jarzab, M., Holte, H., Fossa, A., Ploner, F., Mansmann, U., Schmoll, H. J., Simonsson, B., Toscano, Vincenzo, Petersenn, Stephan (Beitragende*r), CCA -Cancer Center Amsterdam, Oncology, Other departments, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, General Internal Medicine, and Endocrinology

Subjects
Adult, Male, adrenal tumor, medicine.medical_specialty, Medizin, Kaplan-Meier Estimate, Gastroenterology, Disease-Free Survival, Streptozocin, Young Adult, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Adrenocortical Carcinoma, Medicine, Adrenocortical carcinoma, Humans, Mitotane, Adverse effect, Etoposide, Aged, Intention-to-treat analysis, business.industry, Medicine (all), Hazard ratio, Combination chemotherapy, General Medicine, Middle Aged, medicine.disease, Adrenal Cortex Neoplasms, Surgery, Intention to Treat Analysis, Regimen, Doxorubicin, Cisplatin, Female, Quality of Life, business, medicine.drug
Abstract

A b s t r ac t Background Adrenocortical carcinoma is a rare cancer that has a poor response to cytotoxic treatment. Methods We randomly assigned 304 patients with advanced adrenocortical carcinoma to re ceive mitotane plus either a combination of etoposide (100 mg per square meter of body-surface area on days 2 to 4), doxorubicin (40 mg per square meter on day 1), and cisplatin (40 mg per square meter on days 3 and 4) (EDP) every 4 weeks or streptozocin (streptozotocin) (1 g on days 1 to 5 in cycle 1; 2 g on day 1 in subsequent cycles) every 3 weeks. Patients with disease progression received the alternative regimen as second-line therapy. The primary end point was overall survival. Results For first-line therapy, patients in the EDP–mitotane group had a significantly higher response rate than those in the streptozocin–mitotane group (23.2% vs. 9.2%, P

Published
2012
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2. Determination of N7-methylguanine in DNA of white blood cells from cancer patients treated with dacarbazine

Author

Delft, J.H.M. van, Ende, A.M.C. van den, Keizer, H.J., Ouwerkerk, J., Baan, R.A., and Centraal Instituut voor Voedingsonderzoek TNO Medisch Biologisch Laboratorium TNO

Subjects
Adult, Male, Guanine, Blood sampling, Clinical article, DNA determination, Enzyme-Linked Immunosorbent Assay, Middle Age, Dose response, Antineoplastic Combined Chemotherapy Protocols, Leukocytes, 7 Methylguanine, Melanoma, Patient monitoring, Sarcoma, DNA, Carmustine, Dacarbazine, Human cell, Cancer patient, Intravenous drug administration, Female, Cisplatin, Support, Non-U.S, Cell level, Human
Abstract

An ELISA method was used to determine N7-methylguanine (N7-MeGua) adducts in DNA of white blood cells from cancer patients treated with the methylating antitumor drug dacarbazine by i.v. administration. From four patients who received dacarbazine only, at dosages of 250, 400 or 800 mg/m2, the blood samples were collected before and several days after administration, and from one patient also during the first few hours. N7-MeGua levels increased rapidly during the first hour after treatment, hardly changed during the following 7 h and decreased during the next days (half-life of ~ 72 h). The adduct levels appeared to be dose-dependent. Blood cells were also analyzed from three patients who received dacarbazine (225 mg/m2) in combination with other chemotherapeutic drugs during three successive days. One of these patients showed a larger initial level of N7-MeGua and a cumulative increase with the dacarbazine dose compared to the other two patients. For several patients adduct levels were monitored during two chemotherapy cycles, for which quite similar data were obtained. Chemicals/CAS: 7 methylguanine, 578-76-7; carmustine, 154-93-8; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; dacarbazine, 4342-03-4; 7-methylguanine, 578-76-7; Antineoplastic Combined Chemotherapy Protocols; Dacarbazine, 4342-03-4; DNA, 9007-49-2; Guanine, 73-40-5

Published
1992

3. When people fall from grace: Reconsidering the role of envy in schadenfreude

Author

Marcello Gallucci, Wilco W. van Dijk, Jaap W. Ouwerkerk, Sjoerd Goslinga, M. Nieweg, Dijk, W, Ouwerkerk, J, Goslinga, S, Nieweg, M, Gallucci, M, Social Psychology, Communication Science, and Communication Choices, Content and Consequences (CCCC)

Subjects
Adult, Male, media_common.quotation_subject, Emotions, schadenfreude, emozioni, Jealousy, Hostility, Pleasure, Sex Factors, Social cognition, medicine, Humans, Social Behavior, General Psychology, Netherlands, media_common, Social comparison theory, SDG 5 - Gender Equality, Social perception, Schadenfreude, Regression Analysis, Female, medicine.symptom, Psychology, Social psychology, Misfortune, Cognitive psychology
Abstract

Previous research yielded conflicting results concerning the role of envy in predicting Schadenfreude (pleasure at another's misfortune). Some studies showed that envy predicts Schadenfreude, whereas others did not. Results of the present research reconcile these opposing findings, by showing that envy is a predictor of Schadenfreude when the target is similar to the observer in terms of gender. These results suggest that envy predicts Schadenfreude when people are confronted with the misfortune of a relevant social comparison other. Copyright 2006 by the American Psychological Association.

Published
2006
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