1. Liver Stiffness on Magnetic Resonance Elastography and the MEFIB Index and Liver-Related Outcomes in Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-Analysis of Individual Participants
- Author
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Veeral Ajmera, Beom Kyung Kim, Kun Yang, Abdul M. Majzoub, Tarek Nayfeh, Nobuharu Tamaki, Namiki Izumi, Atsushi Nakajima, Ramazan Idilman, Mesut Gumussoy, Digdem Kuru Oz, Ayse Erden, Natalie E. Quach, Xin Tu, Xinlian Zhang, Mazen Noureddin, Alina M. Allen, and Rohit Loomba
- Subjects
Liver Cirrhosis ,Adult ,Male ,Varices ,Carcinoma, Hepatocellular ,Nonalcoholic Fatty Liver Disease ,Chronic Liver Disease and Cirrhosis ,Clinical Sciences ,Oral and gastrointestinal ,Paediatrics and Reproductive Medicine ,Non-alcoholic Fatty Liver Disease ,Clinical Research ,Humans ,Aged ,Gastroenterology & Hepatology ,Hepatology ,Liver Disease ,Carcinoma ,Liver Neoplasms ,Neurosciences ,Gastroenterology ,Ascites ,Hepatocellular ,Portal Hypertension ,Middle Aged ,Fibrosis ,Magnetic Resonance Imaging ,Good Health and Well Being ,Liver ,Cirrhosis ,Elasticity Imaging Techniques ,Female ,Digestive Diseases ,Biomarkers - Abstract
Background & aimsMagnetic resonance elastography (MRE) is an accurate biomarker of liver fibrosis; however, limited data characterize its association with clinical outcomes. We conducted an individual participant data pooled meta-analysis on patients with nonalcoholic fatty liver disease to evaluate the association between liver stiffness on MRE and liver-related outcomes.MethodsA systematic search identified 6 cohorts of adults with nonalcoholic fatty liver disease who underwent a baseline MRE and were followed for hepatic decompensation, hepatocellular carcinoma, and death. Cox and logistic regression were used to assess the association between liver stiffness on MRE and liver-related outcomes, including a composite primary outcome defined as varices needing treatment, ascites, and hepatic encephalopathy.ResultsThis individual participant data pooled meta-analysis included 2018 patients (53% women) with a mean (± standard deviation) age of 57.8 (±14) years and MRE at baseline of 4.15 (±2.19) kPa, respectively. Among 1707 patients with available longitudinal data with a median (interquartile range) of 3 (4.2) years of follow-up, the hazard ratio for the primary outcome for MRE of 5 to 8 kPa was 11.0 (95% confidence interval [CI]: 7.03-17.1, P < .001) and for ≥ 8 kPa was 15.9 (95% CI: 9.32-27.2, P < .001), compared with those with MRE
- Published
- 2022
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