1. Relationships between cytokine (IL-6 and TGF-β1) gene polymorphisms and chromosomal damage in hospital workers
- Author
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Eleonora Manitta, Michela Chiarizio, Alfredo Santovito, Massimiliano Delpero, Giulia Meschiati, Piero Cervella, Marta Delsoglio, and Giulia Picco
- Subjects
Adult ,Male ,0301 basic medicine ,Genotype ,medicine.medical_treatment ,Immunology ,Chromosome Disorders ,chromosomal aberration ,immunogenetics ,pathologists ,Sister chromatid exchange ,Toxicology ,Locus (genetics) ,Biology ,Xenobiotics ,Transforming Growth Factor beta1 ,03 medical and health sciences ,Gene Frequency ,medicine ,Humans ,Genetic Predisposition to Disease ,Allele ,Interleukin 6 ,Allele frequency ,Chromosome Aberrations ,Inflammation ,Polymorphism, Genetic ,Interleukin-6 ,Heterozygote advantage ,Environmental Exposure ,Environmental exposure ,Middle Aged ,Personnel, Hospital ,030104 developmental biology ,Cytokine ,Leukocytes, Mononuclear ,biology.protein ,Female ,DNA Damage - Abstract
Cytokine gene polymorphisms have been found to be associated with a pre-disposition to a variety of diseases, including inflammatory and cancer diseases. The present study evaluated the influence of six cytokine gene polymorphisms on the level of genomic damage observed in peripheral blood lymphocytes from hospital pathologists chronically exposed to low doses of different xenobiotics. Lymphocytes from 50 pathologists and 50 control subjects were recruited and analyzed in Sister Chromatid Exchange (SCE) and Chromosomal Aberrations (CA) assays. The frequencies of six cytokine gene polymorphisms and their relationships with the cytogenetic damage levels were also evaluated. The results indicated that significant differences were found between pathologists and controls in terms of SCE frequency (p
- Published
- 2015