1. Hypofractionated Radiotherapy With Simultaneous-integrated Boost After Breast-conserving Surgery Compared to Standard Boost-applications Using Helical Tomotherapy With TomoEdge
- Author
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Michael Schempp, Sebastian Hoefel, Peter E. Huber, Felix Zwicker, Juergen Debus, and Corinna Kirchner
- Subjects
Adult ,Organs at Risk ,Simultaneous integrated boost ,Hypofractionated Radiotherapy ,Cancer Research ,medicine.medical_treatment ,Breast Neoplasms ,Mastectomy, Segmental ,Tomotherapy ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Hypofractionated radiotherapy, simultaneous integrated boost, SIB, breast cancer, helical tomotherapy, TomoEdge, IMRT ,Breast-conserving surgery ,medicine ,Humans ,Dosimetry ,ddc:610 ,Lung ,Adjuvant radiotherapy ,business.industry ,Radiotherapy Planning, Computer-Assisted ,Heart ,General Medicine ,Reference Standards ,medicine.disease ,Tumor Burden ,Radiation therapy ,Oncology ,030220 oncology & carcinogenesis ,Female ,Radiation Dose Hypofractionation ,Radiotherapy, Adjuvant ,Radiotherapy, Intensity-Modulated ,Nuclear medicine ,business - Abstract
This comparative plan study examines a range of boost-radiation methods in adjuvant radiotherapy of breast cancer using helical intensity-modulated radiotherapy with TomoEdge-technique. Impact of hypofractionated radiation with simultaneous-integrated boost (SIB) and influence of differing assumed α/β-values were examined.Background/Aim: This comparative plan study examines a range of boost-radiation methods in adjuvant radiotherapy of breast cancer using helical intensity-modulated radiotherapy with TomoEdge-technique. Impact of hypofractionated radiation with simultaneous-integrated boost (SIB) and influence of differing assumed α/β-values were examined. Patients and Methods: For 10 patients with left-sided breast cancer each four helical IMRT-plans with TomoEdge-technique were created: hypofractionated+SIB (H-SIB) (42.4/54.4 Gy, 16 fractions), normofractionated+SIB (N-SIB) (50.4/64.4 Gy, 28 fractions), hypofractionated+sequential-boost (H-SB) (42.4 Gy/16 fractions+16 Gy/8 fractions), normofractionated+ sequential-boost (N-SB) (50.4 Gy/28 fractions+16 Gy/8 fractions). Equivalent doses (EQD2) to organs-at-risk (OAR) and irradiated mammary-gland were analysed for different assumed α/β-values. Results: The mean EQD2 to OAR was significantly lower using hypofractionated radiation-techniques. H-SIB and H-SB were not significantly different. H-SIB and N-SIB conformed significantly better to the breast planning-target volume (PTV) and boost-volume (BV) than H-SB and N-SB. Regarding BV, mean EQD2 was significantly higher for all α/β-values investigated when using H-SIB and N-SIB. Regarding PTV, there were no clinically relevant differences. Conclusion: Relating to dosimetry, H-SIB is effective compared to standard-boost-techniques. published
- Published
- 2021