1. Expression of Fas and Fas ligand in human testicular germ cell tumours
- Author
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E. Marchioni, Loredana Gandini, Enke Baldini, Elisa Petrangeli, Steno Sentinelli, Andrea Lenzi, Salvatore Ulisse, A Di Benedetto, M. D’Armiento, R. P. Donnorso, M. G. Reale, G. Giovannetti, and Marcella Mottolese more...
- Subjects
fas ligand ,Adult ,Male ,germ cells ,medicine.medical_specialty ,Fas Ligand Protein ,fas ,fasl ,seminoma ,testis ,tumour ,Urology ,Endocrinology, Diabetes and Metabolism ,Testicle ,Biology ,Fas ligand ,Andrology ,Young Adult ,Testicular Neoplasms ,Internal medicine ,Biomarkers, Tumor ,medicine ,Humans ,RNA, Messenger ,fas Receptor ,Orchiectomy ,Testicular cancer ,Reverse Transcriptase Polymerase Chain Reaction ,Cancer ,Seminoma ,Middle Aged ,medicine.disease ,medicine.anatomical_structure ,Endocrinology ,Reproductive Medicine ,Cancer cell ,Disease Progression ,Immunohistochemistry - Abstract
Summary In the present study, we analysed the expression of Fas ligand (FasL) and its cognate receptor Fas in 14 seminomatous testicular germ cell tumours (TGCT) and six normal testicular tissues obtained following orchiectomy. Tissue samples have been processed to prepare either total RNA or protein extracts or fixed and embedded in paraffin for immunohistochemistry (IHC) experiments. Quantitative RT-PCR experiments demonstrated in TGCT a significant (p more...
- Published
- 2009
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