1. A comparative study of short- and long-TE ¹H MRS at 3 T for in vivo detection of 2-hydroxyglutarate in brain tumors
- Author
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Changho, Choi, Sandeep, Ganji, Keith, Hulsey, Akshay, Madan, Zoltan, Kovacs, Ivan, Dimitrov, Song, Zhang, Kumar, Pichumani, Dianne, Mendelsohn, Bruce, Mickey, Craig, Malloy, Robert, Bachoo, Ralph, Deberardinis, and Elizabeth, Maher
- Subjects
Adult ,Aspartic Acid ,Magnetic Resonance Spectroscopy ,Brain Neoplasms ,Phantoms, Imaging ,Glutamine ,Glutamic Acid ,Glioma ,Middle Aged ,Isocitrate Dehydrogenase ,Article ,Glutarates ,Young Adult ,Mutation ,Humans ,Protons ,gamma-Aminobutyric Acid - Abstract
2-Hydroxyglutarate (2HG) is produced in gliomas with mutations of isocitrate dehydrogenase (IDH) 1 and 2. The (1) H resonances of the J-coupled spins of 2HG are extensively overlapped with signals from other metabolites. Here, we report a comparative study at 3 T of the utility of the point-resolved spectroscopy sequence with a standard short TE (35 ms) and a long TE (97 ms), which had been theoretically designed for the detection of the 2HG 2.25-ppm resonance. The performance of the methods is evaluated using data from phantoms, seven healthy volunteers and 22 subjects with IDH-mutated gliomas. The results indicate that TE = 97 ms provides higher detectability of 2HG than TE = 35 ms, and that this improved capability is gained when data are analyzed with basis spectra that include the effects of the volume localizing radiofrequency and gradient pulses.
- Published
- 2012