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Objective To estimate four radiomorphometric indices of mandibular bones in an 18th century population sample, and possibly associate the findings with bone mass loss related to sex, age, nutritional habits and pathologies reflecting on the bone. Design Thirty-six sculls (31 males, 5 females), recovered from the crypt of Požega Cathedral in Croatia were analyzed. Age estimation was based on tooth wear, and Eichner class was determined according to the number of occlusal supporting zones. The parameters in recording analogue orthopantomographs were set to constant current of 16 mA, exposure time of 14.1 s, and voltage between 62–78 kV. Films were processed in an automatic dark chamber processor for 12 min, and digitized at 8-bit, 300 dpi. The thickness of the mandibular cortex was assessed below the mental foramen (MI), at antegonion (AI), at gonion (GI). Qualitative mandibular cortical index (MCI) was assessed. Results Average values of MI, AI and GI were 3.97 ± 0.94 mm, 2.98 ± 0.56 mm, and 1.99 ± 0.55 mm, respectively. Statistically significant differences between males and females were found for AI right (p = 0.014), GI left (p = 0.010) and GI average (p = 0.006), and were in all cases higher in males. There were no statistically significant differences between age groups for either index (p > 0.05). Considering Eichner classification the differences were not significant for MI (p = 0.422), AI (p = 0.516), and GI (p = 0.443), but in Eichner classes II, MCI was significantly higher (p = 0.02). Conclusion The obtained data does not suggest generalized malnutrition or calcium, phosphorus and vitamin D deprivation in the historic population studied.

The purpose of this study was to determine the range of threshold responses of healthy dental pulps and test the reproducibility of the electric pulp test (EPT). Forty‐nine dental students participated in the study. Sound teeth in both arches, except third molars, were included. The teeth were isolated using cotton rolls and dried with compressed air, and the threshold responses were recorded. Participants stopped the stimulus increase by pressing the switch at the first sensation of discomfort. The measurements were repeated after 30 days. The obtained data were analysed using SPSS®16.0. The mean thresholds for the maxillary incisors, canines, premolars and molars were 10.77, 21.07, 21.88 and 34.07 μA, and for mandibular incisors, canines, premolars and molars 9.81, 18.7, 19.24 and 30.1 μA respectively. The differences between the two measurements were statistically significant for teeth 32, 31, 41 and 42. The EPT was shown to be reproducible for all the teeth tested except mandibular incisors.

The purpose of the research was to compare oral health behavior and plaque indices between Croatian first-year and final-year dental students. Therefore, 46.9% of first-year and 47% of final-year dental students were surveyed using the Hiroshima University Dental Behavior Inventory (HU-DBI) questionnaire and had their plaque indices determined. Descriptive statistics analysis, nonparametric tests, and correlation analysis were performed (p

Svrha: Epidemiološka istraživanja u mnogim zemljama pokazuju neravnomjernu raspodjelu oralnih bolesti u populaciji – primarno karijesa, te je zato glavna svrha ovoga presječnog istraživanja bila dobiti relevantne podatke oralnog statusa populacije u Kninu i okolici određene prema smjernicama SZO-a. Ispitanici i metode: U istraživanje je bilo uključeno 414 ispitanika u dobi od 18 do 65 godina. Zabilježeni podatci uključivali su opću anamnezu, ekstraoralni status, status oralne sluznice, status temporpomandibularnih zglobova, zubni, parodontni i protetski status, te jesu li potrebni restaurativni zahvati. Obavljena je i usporedba među različitim grupama, ovisno o dobi, spolu, stupnju obrazovanja i podrijetlu. Rezultati: Prosječno je KEP indeks bio 17,3, zatim 1,7 – karijes, 6,2 – ispuni i 9,4 – ekstrahirani zubi. SIC indeks iznosio je 26,4. Razlika je bila značajna u grupama prema dobi i stupnju obrazovanja (p < 0,001). Postotak osoba s najvišim zbrojem CPI-a od 0 do 4 bio je 27,3, 16,9, 36,5, 16,4, i 2, 2,9 posto. Razlika između dobnih grupa u CPI vrijednostima bila je statistički značajna, a razlika ovisno o spolu i podrijetlu nije bila značajna (p = 0,001). Zaključak: Populacija u Kninu i okolici ima vrlo loš oralni status, najvjerojatnije zbog posljedica rata 1990-ih godina i ekonomske tranzicije te zato što nema nacionalnog programa za promicanje oralnoga zdravlja., The aim: Epidemiologic studies in many countries show uneven distribution of oral diseases (primarily caries) within the population. This is why more studies are oriented towards specific regions or subpopulations instead of large scale national surveys. The major purpose of this cross sectional study was to obtain relevant data about the oral status of the population of Knin and its surroundings according to the WHO criteria. Subjects and methods: The study included 414 participants aged between 18 and 65. The recorded variables included general anamnestic data, extraoral status, oral mucosa status, temporomandibular joint status, dental, periodontal and prosthetic status, and the need for dental restoration. The comparison between different groups regarding age, gender, educational level and origin was made. Results: DMFT index was 17.3 – with on average 1.7 caries, 6.2 fillings, and 9.4 teeth extracted. SiC index equaled 26.4. The difference was significant regarding the level of education and age (p

Background. Keratocystic odontogenic tumor (KCOT) is a benign, yet aggressive odontogenic tumor. Herein, proteome analysis of KCOT lesions in comparison with control patient-matched tissue unaffected by the disease and with inflammatory odontogenic cysts, namely radicular cysts is presented. Methods. For the proteomics profiling, two complementary proteomics techniques MALDI-MS/MS and LC-ESI-MS/MS were employed. Potential candidate biomarkers were validated by immunohistochemistry. Results. More than 43 proteins were found to be differentially expressed or up-regulated in KCOT lesions in comparison with patient-matched unaffected oral mucosa. These proteins bear important biological functions and are involved in cell proliferation, cytoskeletal re-organization, transcription, cellular motility and apoptosis. In particular, a number of differentially expressed proteins participate in autocrine regulation and signalization within JNK and p38 MAPK signaling pathways. Conclusions. Immunohistochemical validation of chosen putative biomarkers revealed axin interaction partner and dorsalization- antagonist (AIDA), known as a protein that blocks activation of JNK signalling pathway , as a differential biomarker for KCOT lesions on an independent cohort of KCOT tissue samples in comparison with most prevalet intraoseal lesions inflammatory odontogenic cysts.

The purpose of this study was to determine the prevalence of third molars in terms of respondents' age. Furthermore it was desired to determine the extent of the manifestation of pathological changes, such as caries, apical lesions, and alveolar bone resorption. This study was based on 500 OPGs of patients from the Faculty of Dentistry, University of Zagreb. Patients were divided into seven age groups. The total number of molars, the number of cavities on remaining molars, the quality of endodontic treatment and the evaluation of their performance and presence of periapical lesions was analyzed. As apart of the periodontal status, the number of inadequate fillings, the number of damaged furcations and bone resorption was analyzed. The statistical analysis was performed by means of STATISTICA 7 statistical package (StatSoft, Tulsa, USA). The correlation between the total number of molars and the age of patients was analyzed by means of Spearman's correlation to the level of significance of 0.05. The number of first, second and third molars significantly decreased in higher age groups. The prevalence of caries in third molars as compared to first and second molars was generally lower, third molars were endodontic treated at least. Assessment of involved furcations showed that the lowest percentage of 8% was found in third molars. The majority of all remaining molars had bone resorption of 1-3 mm.

Objective: The aim was to examine dental and periodontal status of adult Croatian 18th century population and compare the results with available literature data. Materials and methods: 104 specimens from the crypt of Poz y ega cathedral were grouped into three female and three male groups according to age. Caries was determined by visual inspection and dental probe. Ante and post mortem teeth losses were recorded. Periodontal status was determined according to the length of exposed tooth root from alveolar crest to cemento-enamel junction. The presence of dehiscences and fenestrations was recorded on facial and oral plate of alveolar bone. Results: The whole sample exhibited ante- and post mortem teeth loss of 19.57% and 24.91%, respectively. The teeth most frequently lost postmortem were incisors. The canines were best preserved. The frequency of caries in both jaws was the highest in molars (26.63% in maxilla and 28.10% in mandible), whilst central incisors exhibited the least carious lesions (11.59 and 1.92%). The most frequently affected surfaces were occlusal, then proximal and facio-oral. The percentage of teeth with either moderate or considerable bone loss was higher in females. The frequency of considerable bone loss increased significantly with age. The frequency of dehiscences was 3.11%. It was higher in maxilla than in the mandible. The frequency of fenestrations was 5.65% and it was significantly higher in maxilla. Conclusions: The results demonstrate poor oral health amongst 18th century population of continental Croatia, exhibiting high antemortem teeth loss, high periodontal disease frequency and occlusal and proximal caries frequency.