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To study further the effect of head-down tilt (HDT) on slow positive potential in the event-related potentials (ERPs), the temporal and spatial features of visual ERPs changes during 2 hour HDT (-10 degrees) were compared with that during HUT (+20 degrees) in 15 normal subjects. The stimuli were consisted of two color LED flashes appeared randomly in left or right visual field (LVF or RVF) with same probability. The subjects were asked to make switch response to target signals (T) differentially: switching to left for T in LVF and to right for T in RVF, ignoring non-target signals(N). Five sets of tests were made during HUT and HDT. ERPs were obtained from 9 locations on scalp. The mean value of the ERPs in the period from 0.32-0.55 s was taken as the amplitude of slow positive potential(P400). The main results were as follows. 1) The mean amplitude of P400 decreased during HDT which was more significant at the 2nd, 3rd and 5th set of tests; 2) spatially, the reduction of mean P400 amplitude during HDT was more significant for signals from RVF and was more significant at posterior and central brain regions than that on frontal locations. As that the positive potential probably reflects the active inhibition activity in the brain during attention process, these data provide further evidence showing that the higher brain function was affected by the simulated weightlessness and that this effect was not only transient but also with interesting spatial characteristics.

The characteristics change of brain response was studied during 15 degrees head-down tilt (HDT) comparing with 45 degrees head-up tilt (HUT). The brain responses evaluated included the EEG power spectra change at rest and during mental arithmetic, and the event-related potentials (ERPs) of somatosensory, selective attention and mental arithmetic activities. The prominent feature of brain response change during HDT revealed that the brain function was inhibited to some extent. Such inhibition included that the significant increment of "40Hz" activity during HUT arithmetic almost disappeared during HDT arithmetic, and that the positive-potential effect induced by HDT presented in all kinds of ERPs measured, but the slow negative wave reflecting mental arithmetic and memory process was elongated. These data suggest that the brain function be affected profoundly by the simulated weightlessness, therefore, the brain function change during space flight should be studied systematically.

Event-related EEG spectral perturbation (ERSP) was studied in 20 right-handed subjects during selective response (SRP) and selective mental arithmetic (SMA). The input signals were one-digit number sounds (single syllable). The subjects were asked to make switch response (for SRP) or accumulative summation (for SMA) as soon as odd numbers (T) were heard and to ignore even ones (N). EEG powers were derived from 3 successive 0.5 s segments post input signal from 9 locations on scalp in 4 conditions (srT, srN, maT and maN). The ERSP was taken as the spectral change relative to that under rest control. The main results were: (i) the power of delta and theta activity increased significantly in the 1st 0.5 s in all 4 conditions but decreased in the following epochs; (ii) the theta activity revealed greatest spatial differentiation, prominent theta activity remained at Fz in the 2nd and 3rd 0.5 s in maT but not in srT; (iii) the power of alpha activity was lowest in the 1st 0.5 s and remained low level during SMA but increased in the 2nd 0.5 s during SRP; (iv) the 11–18 Hz activity augmented after the 1st 0.5 s, its dominance remained at P6 during SMA but switched from P6 to frontal locations during SRP; (v) the power of high frequency activities beyond 30 Hz decreased significantly during SRP at all locations. The temporal and spatial feature of ERSP in the 4 conditions provided further evidence indicating the functional correlates of EEG activities in each frequency band. The high frequency activity might reflect the general attention state. The dynamic change of attentional demand during information processing was probably reflected by alpha activity. The delta, theta and beta activities seemed related to different aspects of cognitive processes.