1. Aripiprazole and ropinirole treatment for cocaine dependence: evidence from a pilot study
- Author
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V. Cellesi, D. Cecconi, M. Moncini, M. Ameglio, G. Simoni, Paola Rucci, L. Biasci, R. N. Forgione, M. Pellegrini, M. Meini, Meini M, Moncini M, Cecconi D, Cellesi V, Biasci L, Simoni G, Ameglio M, Pellegrini M, Forgione RN, and Rucci P.
- Subjects
Adult ,Male ,Indoles ,Visual analogue scale ,Aripiprazole ,Craving ,Pilot Projects ,Pharmacology ,Quinolones ,Piperazines ,Cocaine dependence ,law.invention ,Cocaine-Related Disorders ,Young Adult ,Randomized controlled trial ,law ,Drug Discovery ,Medicine ,Humans ,Psychiatric Status Rating Scales ,Dose-Response Relationship, Drug ,business.industry ,drug treatment ,Middle Aged ,medicine.disease ,Ropinirole ,Treatment Outcome ,Tolerability ,Anesthesia ,Dopamine Agonists ,Clinical Global Impression ,Linear Models ,Female ,medicine.symptom ,business ,COCAINE ,RCT ,medicine.drug ,Antipsychotic Agents - Abstract
BACKGROUND: Currently, there is no specific pharmacological therapy with established efficacy for the treatment of cocaine dependence. The aim of this study was to determine the safety, tolerability and the effects of aripiprazole and ropinirole in patients with cocaine dependence. METHODS: This randomized clinical trial of 12-week duration was carried out on 28 consecutive patients with cocaine dependence presenting for treatment. The diagnostic assessment was performed using ICD-9-CM criteria and Mini International Neuropsychiatric Interview. The Clinical Global Impression Scale, a Visual Analogue Scale to assess craving and a self-report questionnaire on the use of cocaine were administered at baseline and then weekly throughout the study. Urinalyses were carried out three times per weeks to search for benzoylecgonine. RESULTS: Of the 28 study participants, 14 completed the protocol. Treatment discontinuation was unrelated with side effects. One patient required a dosage reduction of ropinirole because of sleepiness and one patient assigned to aripiprazole who reported moderate akathysia had the dosage reduced to 5 mg/day. Routine blood works did not show significant changes from baseline and the overall proportion of positive urinalyses for benzoylecgnonine did not differ significantly between treatments. Using linear mixed-effect models a significant decrease in craving was found in the overall sample (p
- Published
- 2011