1. Anal cancer FDG-PET standard uptake value: correlation with tumor characteristics, treatment response and survival
- Author
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Gianmauro Sacchetti, Lucia Turri, Marco Brambilla, Carola Perotti, Letizia Deantonio, Maria Elisa Milia, Tiziana Cena, and Marco Krengli
- Subjects
Adult ,Male ,Positron emission tomography ,18) F-fluorodeoxyglucose ,Anal cancer ,Prognosis ,Standardized uptake value ,Biopsy ,Contrast Media ,Multimodal Imaging ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Fluorodeoxyglucose F18 ,Statistical significance ,Humans ,Medicine ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Stage (cooking) ,Aged ,Neoplasm Staging ,Neuroradiology ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Histology ,Chemoradiotherapy ,General Medicine ,Middle Aged ,Anus Neoplasms ,medicine.disease ,Primary tumor ,Survival Rate ,Treatment Outcome ,Positron-Emission Tomography ,030220 oncology & carcinogenesis ,Female ,Radiopharmaceuticals ,Tomography, X-Ray Computed ,business ,Nuclear medicine - Abstract
The present work studies the correlation of (18) F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) standardized uptake value (SUV) with tumor characteristics, clinical response and prognosis in a series of anal canal cancer patients treated with chemo-radiotherapy. Fifty-five patients were included in the present analysis. PET maximum SUV (SUVmax) of primary tumor was calculated for each patient. The correlation with clinical parameters, tumor response and survival data were analyzed. SUVmax significantly correlated with T-stage (p = 0.01) and histology (p = 0.03). Median SUVmax was higher for lesions with partial response (PR, 21/55, 38 %) than for lesions with complete response (CR, 34/55, 62 %) but without statistical significance (p = 0.17). The actuarial disease-free survival (DFS) and overall survival (OS) rates were 53.0 and 77.8 % at 2 years and 41.3 and 58.6 % at 5 years, respectively. Median SUVmax did not statistically correlate with clinical response or survival. CR and T1–T2 stage were statistically significant prognostic factors for disease-free survival (p
- Published
- 2015
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