1. Prevalence and 20-year epidemiological trends of glomerular diseases in the adult Saudi population: a multicenter study
- Author
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Hanadi Alhozali, Hala Kfoury, Khaled O. Alsaad, Noura Al Oudah, Lamees I Al-mezaini, Sufia Husain, Abdulkareem Alsuwaida, Ghadeer A Mokhtar, Abdulrahaman Alabdulsalam, Junaid J. Wadera, Talal AlFaadhel, Rehan Ahmed Siddiqui, Feras A. Alsuwaida, Ammar Bakheet, Majed M Alanazi, Mahmoud Yassin AlHamad, Mohamed Kechrid, Ashraf Abdelrehman, and Noura Ahmed more...
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Adult ,Male ,medicine.medical_specialty ,Pediatrics ,Adolescent ,Biopsy ,Population ,Saudi Arabia ,MEDLINE ,lcsh:Medicine ,030209 endocrinology & metabolism ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Epidemiology ,Prevalence ,medicine ,Humans ,Diabetic Nephropathies ,030212 general & internal medicine ,Young adult ,education ,Aged ,Retrospective Studies ,education.field_of_study ,Glomerulosclerosis, Focal Segmental ,business.industry ,Incidence ,Incidence (epidemiology) ,lcsh:R ,Glomerulosclerosis ,Glomerulonephritis, IGA ,Glomerulonephritis ,Retrospective cohort study ,General Medicine ,Middle Aged ,medicine.disease ,Lupus Nephritis ,Original Article ,Female ,Kidney Diseases ,sense organs ,business - Abstract
BACKGROUND: Recent international reports have shown significant changes in the incidence of different glomerular diseases. OBJECTIVE: Examine temporal and demographic trends of biopsy-diagnosed glomerular diseases in the adult population of Saudi Arabia over the last two decades. DESIGN: Medical record review. SETTINGS: Four tertiary medical centers in Saudi Arabia. PATIENTS AND METHODS: We identified all patients that underwent native kidney biopsy between 1998 and 2017. MAIN OUTCOME MEASURES: The frequency and the disease trends in four biopsy eras (1998–2002, 2003–2007, 2008–2011, and 2012–2017) for different glomerular diseases. SAMPLE SIZE AND CHARACTERISTICS: 1070 patients, 18-65 years of age; 54.1% female. RESULTS: Of 1760 patients who underwent native kidney biopsies, 1070 met inclusion criteria. Focal segmental glomerulosclerosis was the most common biopsy-diagnosed disease, with comparable frequencies over the four eras (23.6%, 19.8%, 24.1%, and 17.1, respectively [P value for trend=.07]). The frequency of immunoglobulin A nephropathy increased progressively. The incidence of membranoproliferative glomerulonephritis declined significantly. Among the secondary types of glomerular diseases, systemic lupus erythematosus-associated lupus nephritis was the most common, followed by diabetic nephropathy. The prevalence of diabetic nephropathy increased from 1.4% in the first era to 10.2% in the last one. CONCLUSIONS: Trends in biopsy-diagnosed glomerular disease have changed. While focal segmental glomerulosclerosis remains the most common glomerular disease, there has been a significant rise in the prevalence of immunoglobulin A nephropathy and diabetic nephropathy. In contrast, membranoproliferative glomerulonephritis has declined. LIMITATIONS: Retrospective methodologies are vulnerable to lost data. CONFLICT OF INTEREST: None. more...
- Published
- 2019
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