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The task of the study was to determine the influence of emotional-motivational sphere on the phenomenon of out-of-logic mental activity. An accepted in the laboratory model of the recognition of a hidden image double image pictures was used. Recorded multichannel EEG was analysed by the method of computation of coefficients of community elaborated in the laboratory. The results of computation were presented in a form of a stereometric map. The obtained results testify to the fact that the emotional-motivational processes influence the mechanism of the out-of-logic form of decision making. At the out-of-logic form of decision making a subjective evaluation of results dominates being reflected in the character of the spatial distribution of coefficient of community.

The task of the study was to determine the influence of emotional-motivational sphere on the phenomenon of out-of-logic mental activity. An accepted in laboratory model of recognition of concealed image in double image pictures was used. The electrical activity, recorded was analyzed by means of the method of computation of coefficient of community, elaborated in the laboratory, the results were presented in the from of stereometric map. The obtained results testify to the fact that emotional-motivational processes influence the mechanism of out-of-logic form of making solution; at out-of-logic form of making solution subjective evaluation of results dominates, what is reflected in the character of spatial distribution of coefficient of community.

The aim of the study was an attempt to record neurophysiological processes connected with the mechanism of subconscious brain activity. Created in the laboratory method of construction of a topographical map of electrical processes interactions in 24 recorded points was applied. The obtained data testify that identification of evident and latent images in "double image pictures" is accompanied by similar relief of topomaps of interactions. Effect of "sudden vision" of latent image in a manner of "insight" is gradually prepared neurophysiologically, but is not realized by the subject and only at the last stage reaches the consciousness and is verbalized.

Eight subjects were studied by the method of topographic mapping of interconnection characteristics of the human brain electrical activity in the process of recognition of visual images. The method used in our studies differs from others by the fact that properties of the processes interconnections are mapped but not the characteristics of the very processes. Under recognition of images the relief of topographic map of interconnections of cortical electrical processes increases in the right and decreases in the left frontal areas. Thus both hemispheres participate in this process. The hypothesis is suggested about two types of spatial synchronization: of similar electrical activity and of the activity differentiated in the brain sections. The developed method proved to be informative for the studied structure of spatial-temporal organization of the human brain electrical activity.

The radioimmunochemical study of ceruloplasmin-synthesizing polyribosomes was carried out using bioptic liver specimens obtained from fourteen homozygous patients with hepatolenticular degeneration (Wilson--Konovalov disease) and from eight control patients with various non-hereditary diseases. The measurement of binding of 125I-antibodies to the nascent polysome-bound ceruloplasmin chains demonstrated that in control patients this protein is only synthesized on membrane-bound polysomes, while free polysomes do not contribute to the synthesis of ceruloplasmin. The majority of homozygous carriers of Wilson--Konovalov mutation (eleven of fourteen) are characterized by the involvement of free, rather than membrane-bound polysomes, in the synthesis of ceruloplasmin. This shift of ceruloplasmin synthesis from membrane-bound to free polysomes seems to be accompanied by disturbances in the cotranslational proteolytic maturation of ceruloplasmin from its biosynthetic precursors. As a result of this defect, a putative of ceruloplasmin (preproceruloplasmin) was detected in the content of Golgi complex as well as in the serum of homozygous patients. This precursor of a molecular weight 84,000 was found neither in Golgi complex, nor in the serum of control subjects.

In previous articles, evidence has been presented which supports the hypothesis that detectable neurophysiological changes occur in the course of affective disorders, mainly of a depressive type. The scope of the present report has been to expand the previous investigation to comprise variables not hitherto taken into account and to present a new approach to the analysis of EEG in psychiatry. This new approach, a systemic structural analysis, follows the concepts borrowed from the general system theory, and is based on the assumption that brain activity can be regarded as a type of hierarchical system. Hints about the theoretical principles beyond a systemic structural analysis of EEG are given, and the point is stressed that possible correlations between, e.g., neurophysiological and clinical variables must be south starting from characteristics which are at a comparable level of integration in both realms. The preliminary findings of an international collaborative study of depressive syndromes are presented. 45 patients suffering from depressive syndromes of different aetiology and of varying severity participated in the study. These were rated by means of a rating scale which permitted a division for further analysis into subgroups according to the main symptomatology. The results show that characteristic neurofunctional structures can be identified which correspond to various symptomatological patterns. The occurrence of pronounced interhemispheric differences in electrical activity, related to the severity of the depressive syndrome, has also found further support in the results of this present investigation.

A study was made of the content of protease alpha 1-inhibitor and of the phenotyping of protease alpha 1-inhibitor subtypes in 666 patients with different chronic non-specific pulmonary diseases. It is concluded that pronounced deficiency of protease alpha 1-inhibitor is of importance in the formation of primary emphysema, chronic obstructive bronchitis and bronchial asthma. The clinical characteristics of obstructive pulmonary diseases marked by protease alpha 1-inhibitor deficiency have been investigated.

Previous investigations from our laboratory have suggested a possible interhemispheric difference in brain functioning in relation to the severity of a depressive psychopathological process. The present study has been carried out to extend the previous findings to comprise a more detailed symptom analysis of the depressive syndrome, several EEG characteristics, and a new method of EEG analysis. 22 depressed patients, most of them previously untreated, participated in the study. The patients were rated by means of a highly reliable rating scale for depression, and an EEG record was obtained from each of them. Analysis of possible relationships among clinical symptoms and EEG characteristics from different parts of the brain showed a complex pattern, quite different for each symptom. First when a systemic structural analysis of the EEG was performed by means of a special computer program, differential EEG syndromes could be identified. Patients with a high level of anxiety-depression showed a more pronounced functional involvement of the left precentral region than less severely ill patients.