1. Determination of a large set of β-adrenergic agonists in animal matrices based on ion mobility and mass separations.
- Author
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Beucher L, Dervilly-Pinel G, Prévost S, Monteau F, and Le Bizec B
- Subjects
- Adrenergic beta-Agonists chemistry, Adrenergic beta-Agonists urine, Animals, Cattle, Databases, Pharmaceutical, Limit of Detection, Molecular Weight, Red Meat analysis, Retina chemistry, Time Factors, Adrenergic beta-Agonists analysis, Adrenergic beta-Agonists isolation & purification, Mass Spectrometry methods
- Abstract
While the coupling of traveling wave ion mobility spectrometry (TWIMS) and mass spectrometry is mainly reported for structural purposes, we studied its potential in enhancing compounds analysis such as growth promoters used in livestock animals at trace concentrations. β-Adrenergic agonists have been selected as model compounds since they exhibit a range of close physicochemical properties leading to analytical issues using classical approaches. In this paper, the potential of Synapt G2-S (Q-TWIM-TOF MS) has been investigated for sensitive and specific detection of a range of these synthetic phenethanolamines in various complex biological matrices (retina, meat, and urine) from bovine considered as relevant in the context of detecting β-adrenergic agonists use in animals. In particular, the specificity of the additional information provided by the TWIMS (i.e., collision cross section) together with the interest of the extra dimension of separation is discussed.
- Published
- 2015
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