1. Myocardial infarction following parenteral beta agonists for asthma in two patients with normal coronary arteries--a call for caution
- Author
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Barilan, Ayelet, Aizikovich, Alex, Somin, Marina, Beilinson, Nick, Basevitch, Alon, Goland, Sorel, and Malnick, Stephen
- Subjects
Heart attack -- Risk factors ,Heart attack -- Research ,Asthma -- Drug therapy ,Asthma -- Research ,Adrenergic beta agonists -- Dosage and administration ,Adrenergic beta agonists -- Complications and side effects ,Artificial respiration -- Health aspects ,Health - Abstract
Background. Severe asthma is often treated with parenteral beta agonists. There is however, no solid evidence supporting this treatment and it is no longer recommended in current guidelines. Methods and Results. We have recently treated two patients who developed a myocardial infarction with elevated serum troponin and angiographically-normal coronary arteries following administration of parenteral beta-agonists. Conclusion. Parenteral beta agonist administration in severe asthma may result in myocardial infarction. In addition there is a possibility of Takatsubo or stress-induced cardiomyopathy. We suggest that parenteral beta-agonists should be used, if at all, with extreme caution. Keywords: beta-agonists | asthma | myocardial infarction, Introduction Asthma is characterized by reversible bronchospasm and beta-adrenergic agonists are one of the cornerstones of treatment, being among the most potent and rapidly acting bronchodilators available. Beta agonists attenuate [...]
- Published
- 2009