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Start Over Author "LIDDLE, G W" Topic adrenal cortex hormones
16 results on '"LIDDLE, G W"'

11. Inhibitors of adrenal steroid biosynthesis.

Author

Temple TE and Liddle GW

Subjects
Adrenal Glands drug effects, Adrenal Glands metabolism, Adrenal Glands physiopathology, Adrenocorticotropic Hormone pharmacology, Aldosterone biosynthesis, Aminoglutethimide pharmacology, Animals, Dichlorodiphenyldichloroethane pharmacology, Dogs, Heparin pharmacology, Heparinoids pharmacology, Humans, Hydrocortisone pharmacology, Hypertension etiology, Metyrapone pharmacology, Phenethylamines pharmacology, Pituitary-Adrenal System drug effects, Pyridines pharmacology, Sodium metabolism, Stress, Physiological, Adrenal Cortex Hormones antagonists & inhibitors, Adrenal Cortex Hormones biosynthesis
Published
1970
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14. Comparative effects of angiotensin and ACTH on cyclic AMP and steroidogenesis in isolated bovine adrenal cells.

Author

Peytremann A, Nicholson WE, Brown RD, Liddle GW, and Hardman JG

Subjects
Adrenal Glands cytology, Adrenal Glands drug effects, Adrenal Glands enzymology, Angiotensin II administration & dosage, Animals, Cattle, Dose-Response Relationship, Drug, Drug Synergism, In Vitro Techniques, Phosphodiesterase Inhibitors, Time Factors, Tritium, Adrenal Cortex Hormones biosynthesis, Adrenal Glands metabolism, Adrenocorticotropic Hormone pharmacology, Angiotensin II pharmacology, Cyclic AMP metabolism
Abstract

The comparative effects of angiotensin II and adrenocorticotropic hormone (ACTH) on cyclic AMP and steroidogenesis were investigated employing isolated bovine adrenal cells from the zona fasciculata. Like ACTH, angiotensin produced a prompt increase in cyclic AMP which preceded the increase in corticosteroid production. Although this increase in cyclic AMP was small when compared to that induced by ACTH, it correlated with the amount of steroidogenesis. This observation is consistent with the view that cyclic AMP is the intracellular mediator of the steroidogenic action of angiotensin. Angiotensin acted synergistically with ACTH on cyclic AMP levels. This synergism was not explained by inhibition of phosphodiesterase activity. Unlike ACTH, angiotensin failed to stimulate adenylate cyclase in broken cell preparations. The observations suggest that more than one mechanism may be involved in effects of ACTH and angiotensin on cyclic AMP levels.

Published
1973
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15. NATURAL HISTORY OF PITUITARY-ADRENAL RECOVERY FOLLOWING LONG-TERM SUPPRESSION WITH CORTICOSTEROIDS.

Author

GRABER AL, NEY RL, NICHOLSON WE, ISLAND DP, and LIDDLE GW

Subjects
17-Hydroxycorticosteroids, Adrenal Cortex Hormones, Adrenal Gland Neoplasms, Adrenal Glands, Adrenocorticotropic Hormone, Arthritis, Arthritis, Rheumatoid, Blood Chemical Analysis, Colitis, Colitis, Ulcerative, Cushing Syndrome, Drug Therapy, Hypoglycemia, Pharmacology, Pituitary Gland, Substance Withdrawal Syndrome, Toxicology, Urine
Published
1964

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