1. A systematic review and meta-analysis of pediatric normative peripheral quantitative computed tomography data
- Author
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Maria Medeleanu, Reza Vali, Shadab Sadeghpour, Rahim Moineddin, and Andrea S. Doria
- Subjects
Systematic review ,Meta-analysis ,Pediatric radiology ,Peripheral quantitative computed tomography ,Children ,Adolescents ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Background: Peripheral-quantitative computed tomography (pQCT) provides an intriguing diagnostic alternative to dual-energy X-ray absorptiometry (DXA) since it can measure 3D bone geometry and differentiate between the cortical and trabecular bone compartments. Objective: To investigate and summarize the methods of pQCT image acquisition of in children, adolescents and/or young adults (up to age 20) and to aggregate the published normative pQCT data. Evidence acquisition: A literature search was conducted in MEDLINE and EMBASE from 1947 to December 2020. Quality of the included articles was assessed using Standards for Reporting of Diagnostic Accuracy (STARD) scoring system and United States Preventative Services Task Force (USPSTF) Study Design Categorization. Seven articles, encompassing a total of 2134 participants, were aggregated in the meta-analysis. Due to dissimilar age groups and scan sites, only seven pQCT parameters of the 4% radius, 4% tibia and 38% tibia were analyzed in this meta-analysis. Evidence synthesis: The overall fixed-effect estimates of trabecular vBMD of the 4% radius were: 207.16 (201.46, 212.86), mg/cm3 in 8 to 9 year-old girls, 210.42 (201.91, 218.93)in 10 to 12 year-old girls, 226.99 (222.45, 231.54) in 12 to 13 year-old girls, 259.97 (254.85, 265.10) in 12 to 13 year-old boys and 171.55 (163.41,179.69) in 16 to 18 year-old girls. 21 of 54 (38.9%) primary papers received a ‘good’ STARD quality of reporting score (
- Published
- 2021
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