5 results on '"Fauth-Bühler, Mira"'
Search Results
2. Dimensions of manic symptoms in youth:psychosocial impairment and cognitive performance in the IMAGEN sample
- Author
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Stringaris, Argyris, Castellanos-Ryan, Natalie, Banaschewski, Tobias, Barker, Gareth J, Bokde, Arun L, Bromberg, Uli, Büchel, Christian, Fauth-Bühler, Mira, Flor, Herta, Frouin, Vincent, Gallinat, Juergen, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Itterman, Bernd, Lawrence, Claire, Nees, Frauke, Paillere-Martinot, Marie-Laure, Paus, Tomas, Pausova, Zdenka, Rietschel, Marcella, Smolka, Michael N, Schumann, Gunter, Goodman, Robert, and Conrod, Patricia
- Subjects
Male ,Bipolar Disorder ,Adolescent ,Intelligence ,Original Articles ,behavioral disciplines and activities ,bipolar ,Mania ,Inhibition, Psychological ,mental disorders ,Humans ,Female ,adolescents ,creativity ,Psychomotor Performance - Abstract
BackgroundIt has been reported that mania may be associated with superior cognitive performance. In this study, we test the hypothesis that manic symptoms in youth separate along two correlated dimensions and that a symptom constellation of high energy and cheerfulness is associated with superior cognitive performance.MethodWe studied 1755 participants of the IMAGEN study, of average age 14.4 years (SD = 0.43), 50.7% girls. Manic symptoms were assessed using the Development and Wellbeing Assessment by interviewing parents and young people. Cognition was assessed using the Wechsler Intelligence Scale For Children (WISC-IV) and a response inhibition task.ResultsManic symptoms in youth formed two correlated dimensions: one termed exuberance, characterized by high energy and cheerfulness and one of undercontrol with distractibility, irritability and risk-taking behavior. Only the undercontrol, but not the exuberant dimension, was independently associated with measures of psychosocial impairment. In multivariate regression models, the exuberant, but not the undercontrolled, dimension was positively and significantly associated with verbal IQ by both parent- and self-report; conversely, the undercontrolled, but not the exuberant, dimension was associated with poor performance in a response inhibition task.ConclusionsOur findings suggest that manic symptoms in youth may form dimensions with distinct correlates. The results are in keeping with previous findings about superior performance associated with mania. Further research is required to study etiological differences between these symptom dimensions and their implications for clinical practice.
- Published
- 2014
3. Dimensions of manic symptoms in youth: psychosocial impairment and cognitive performance in the IMAGEN sample.
- Author
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Stringaris, Argyris, Castellanos‐Ryan, Natalie, Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L., Bromberg, Uli, Büchel, Christian, Fauth‐Bühler, Mira, Flor, Herta, Frouin, Vincent, Gallinat, Juergen, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Itterman, Bernd, Lawrence, Claire, Nees, Frauke, Paillere‐Martinot, Marie‐Laure, Paus, Tomas, and Pausova, Zdenka
- Subjects
HYPOTHESIS ,COGNITION ,STATISTICAL correlation ,FACTOR analysis ,INTELLECT ,INTERVIEWING ,BIPOLAR disorder ,RESEARCH methodology ,QUESTIONNAIRES ,REGRESSION analysis ,RESEARCH evaluation ,RESEARCH funding ,SELF-evaluation ,STRUCTURAL equation modeling ,DATA analysis software ,DESCRIPTIVE statistics ,SYMPTOMS - Abstract
Background It has been reported that mania may be associated with superior cognitive performance. In this study, we test the hypothesis that manic symptoms in youth separate along two correlated dimensions and that a symptom constellation of high energy and cheerfulness is associated with superior cognitive performance. Method We studied 1755 participants of the IMAGEN study, of average age 14.4 years ( SD = 0.43), 50.7% girls. Manic symptoms were assessed using the Development and Wellbeing Assessment by interviewing parents and young people. Cognition was assessed using the Wechsler Intelligence Scale For Children ( WISC- IV) and a response inhibition task. Results Manic symptoms in youth formed two correlated dimensions: one termed exuberance, characterized by high energy and cheerfulness and one of undercontrol with distractibility, irritability and risk-taking behavior. Only the undercontrol, but not the exuberant dimension, was independently associated with measures of psychosocial impairment. In multivariate regression models, the exuberant, but not the undercontrolled, dimension was positively and significantly associated with verbal IQ by both parent- and self-report; conversely, the undercontrolled, but not the exuberant, dimension was associated with poor performance in a response inhibition task. Conclusions Our findings suggest that manic symptoms in youth may form dimensions with distinct correlates. The results are in keeping with previous findings about superior performance associated with mania. Further research is required to study etiological differences between these symptom dimensions and their implications for clinical practice. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
- View/download PDF
4. From gene to brain to behavior: schizophrenia-associated variation in AMBRA1 alters impulsivity-related traits.
- Author
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Heinrich, Angela, Nees, Frauke, Lourdusamy, Anbarasu, Tzschoppe, Jelka, Meier, Sandra, Vollstädt‐Klein, Sabine, Fauth‐Bühler, Mira, Steiner, Sabina, Bach, Christiane, Poustka, Luise, Banaschewski, Tobias, Barker, Gareth J., Büchel, Christian, Conrod, Patricia J., Garavan, Hugh, Gallinat, Jürgen, Heinz, Andreas, Ittermann, Bernd, Loth, Eva, and Mann, Karl
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SCHIZOPHRENIA ,IMPULSIVE personality ,REVERSE genetics ,ALLELES ,OXYGEN in the blood ,MENTAL illness ,NEUROPSYCHOLOGY - Abstract
Recently, genome-wide association between schizophrenia and an intronic variant in AMBRA1 (rs11819869) was reported. Additionally, in a reverse genetic approach in adult healthy subjects, risk allele carriers showed a higher medial prefrontal cortex blood oxygen level-dependent ( BOLD) response during a flanker task examining motor inhibition as an aspect of impulsivity. To test whether this finding can be expanded to further aspects of impulsivity, we analysed the effects of the rs11819869 genotype on impulsivity-related traits on a behavioral, temperament and neural level in a large sample of healthy adolescents. We consider this reverse genetic approach specifically suited for use in a healthy adolescent sample, as these individuals comprise those who will eventually develop mental disorders in which impulsivity is implicated. Healthy adolescents from the IMAGEN study were included in the neuropsychological analysis ( n = 848) and a functional magnetic resonance imaging ( fMRI) task ( n = 512). Various aspects of impulsivity were assessed using the Temperament and Character Inventory- Revised, the Substance Use Risk Profile Scale, the Cambridge Cognition Neuropsychological Test Automated Battery, and the Stop Signal Task ( SST) in the fMRI paradigm. On a behavioral level, increased delay aversion was observed in risk allele carriers. Furthermore, risk allele carriers showed a higher BOLD response in an orbito-frontal target region during the SST, which declined to trend status after Family Wise Error correction. Our findings support the hypothesis that the schizophrenia-related risk variant of rs11819869 is involved in various aspects of impulsivity, and that this involvement occurs on a behavioral as well as an imaging genetics level. [ABSTRACT FROM AUTHOR]
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- 2013
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5. Prediction of alcohol drinking in adolescents: Personality-traits, behavior, brain responses, and genetic variations in the context of reward sensitivity.
- Author
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Heinrich, Angela, Müller, Kathrin U., Banaschewski, Tobias, Barker, Gareth J., Bokde, Arun L.W., Bromberg, Uli, Büchel, Christian, Conrod, Patricia, Fauth-Bühler, Mira, Papadopoulos, Dimitri, Gallinat, Jürgen, Garavan, Hugh, Gowland, Penny, Heinz, Andreas, Ittermann, Bernd, Mann, Karl, Martinot, Jean-Luc, Paus, Tomáš, Pausova, Zdenka, and Smolka, Michael
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ALCOHOL drinking , *LONGITUDINAL method , *STRUCTURAL equation modeling , *HUMAN genetic variation , *TEENAGERS - Abstract
Adolescence is a time that can set the course of alcohol abuse later in life. Sensitivity to reward on multiple levels is a major factor in this development. We examined 736 adolescents from the IMAGEN longitudinal study for alcohol drinking during early (mean age = 14.37) and again later (mean age = 16.45) adolescence. Conducting structural equation modeling we evaluated the contribution of reward-related personality traits, behavior, brain responses and candidate genes. Personality seems to be most important in explaining alcohol drinking in early adolescence. However, genetic variations in ANKK1 (rs1800497) and HOMER1 (rs7713917) play an equal role in predicting alcohol drinking two years later and are most important in predicting the increase in alcohol consumption. We hypothesize that the initiation of alcohol use may be driven more strongly by personality while the transition to increased alcohol use is more genetically influenced. [ABSTRACT FROM AUTHOR]
- Published
- 2016
- Full Text
- View/download PDF
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