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Parent training (PT) interventions reduce the likelihood of youth problematic behaviors, including drug use. However, the dissemination of culturally adapted PT interventions in low‐income Latina/o immigrant communities remains scarce. In this selective prevention study, we examined the extent to which exposure to CAPAS‐Youth, a culturally adapted version of the PT intervention known as GenerationPMTO©, resulted in increased adolescent perception of harm associated with use of alcohol and other drugs. In a randomized controlled trial with 71 Latina/o immigrant families (95% of parents self‐identified as Mexican origin, n = 98), 37 families were allocated to the CAPAS‐Youth intervention condition versus wait‐list control (n = 34 families). According to adolescents' reports at intervention completion, significant increased levels of perceived harm associated with drug use were found for female youths, but not for males. Differential results indicate the importance of tailoring PT prevention interventions according to youths' sex differences (i.e., males vs. females). [ABSTRACT FROM AUTHOR]