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Objective: Irisin is a recently discovered protein and is defined as an adipomyokine. The relation of irisin with carbohydrate metabolism and other hormone parameters have been investigated. However, studies evaluating the relationship between irisin and puberty are limited and inconclusive. The aim was to evaluate serum concentrations of irisin during different pubertal stages in male adolescents., Methods: The study included normal weight pubertal male adolescents between the ages of 13 6/12 -14 11/12 who had entered puberty. Fasting serum irisin concentrations were evaluated, and bioelectrical impedance analysis was used to measure body fat ratio (BFR) and fat-free mass (FFM). BFR was also calculated by caliper measurement of subcutaneous fat at the triceps., Results: Sixty-eight adolescents were enrolled. The number of adolescents in pubertal stage 2, 3, 4 and 5 were n=17 (25%), n=13 (19.1%), n=21 (30.1%) and n=17 (25%), respectively. The median values of the irisin are 8.80, 8.20, 9.15 and 7.24 ng/mL according to the 2-5 pubertal stages, respectively. The levels of circulating irisin did not differ according to the pubertal stage. Additionally, there was no significant relationship between irisin levels and body fat percentage or FFM., Conclusion: Irisin levels do not differ after the onset of puberty or with progressing pubertal maturation. This study strengthens the evidence that there is no change in irisin concentration as puberty progresses. This may have important implications when using this adipomyokine in the future for diagnosis or treatment of obesity-related diseases.

Objective: The aim of this paper is to present a case with premenstrual dysphoric disorder and to review the diagnosis from an adolescent medicine approach, discussing why diagnosis and treatment must be distinct for this age group and different from the adult approach., Introduction: Premenstrual disorder is a periodic, recurrent, debilitating condition with either physical and/or psychological symptoms that occur during the late luteal phase of the menstrual cycle., Case: We report the case of a 16-year-old female diagnosed with premenstrual disorder., Discussion: Physical signs, behavioral changes, and mood disturbances that occur before menstruation have long been recognized in women, but how well is the disorder defined for adolescents? Due to the unique characteristics of teens, do the current diagnostic criteria appropriately represent this population?

Peak bone mass (PBM) is defined as the highest bone mineral content (BMC) reached in any period of a person's life. The bone mass once gained at the peak begins to decline and continues to do so until the end of life. The aim of this study was to evaluate the relationship of nutrition and physical activity on bone mineralization during the adolescent period. The study took place at Hacettepe University Ihsan Doğramaci Children's Hospital Adolescent Unit. One hundred fourteen healthy male adolescents applying for different reasons, with ages ranging between 11.1 and 16.5 years, participated in the study. When all adolescents were evaluated, no statistical relationship between the daily calcium intake, BMC and bone mineral density (BMD) was obtained. However, a positive statistical relationship was found for those participants in Tanner stage I. This result is in support of previous studies stating the importance of calcium intake and bone mineralization in the prepubertal stage, suggested by our findings, which yielded a positive correlation only in the prepubertal stage. One of the reasons for the same effect not being observed in puberty is thought to be due to the hormonal changes and active role of sex steroids. This shows how critical the prepubertal period is for future bone health. During this critical period of prepuberty, the significance of nutritions and physical activity is evident.