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3 results on '"Tac-An, Ilya A."'

1. Reconstruction of 60 Years of Chikungunya Epidemiology in the Philippines Demonstrates Episodic and Focal Transmission

Author

Salje, Henrik, Cauchemez, Simon, Alera, Maria Theresa, Rodriguez-Barraquer, Isabel, Thaisomboonsuk, Butsaya, Srikiatkhachorn, Anon, Lago, Catherine B, Villa, Daisy, Klungthong, Chonticha, Tac-An, Ilya A, Fernandez, Stefan, Velasco, John Mark, Roque, Vito G, Nisalak, Ananda, Macareo, Louis R, Levy, Jens W, Cummings, Derek, and Yoon, In-Kyu

Subjects
Vaccine Related, Clinical Research, Vector-Borne Diseases, Prevention, Infectious Diseases, Infection, Good Health and Well Being, Adolescent, Adult, Aged, Aged, 80 and over, Chikungunya Fever, Child, Child, Preschool, Cluster Analysis, Disease Transmission, Infectious, Female, History, 20th Century, History, 21st Century, Humans, Infant, Infant, Newborn, Male, Middle Aged, Philippines, Young Adult, chikungunya, epidemiology, modeling, serological study, Biological Sciences, Medical and Health Sciences, Microbiology
Abstract

Proper understanding of the long-term epidemiology of chikungunya has been hampered by poor surveillance. Outbreak years are unpredictable and cases often misdiagnosed. Here we analyzed age-specific data from 2 serological studies (from 1973 and 2012) in Cebu, Philippines, to reconstruct both the annual probability of infection and population-level immunity over a 60-year period (1952-2012). We also explored whether seroconversions during 2012-2013 were spatially clustered. Our models identified 4 discrete outbreaks separated by an average delay of 17 years. On average, 23% (95% confidence interval [CI], 16%-37%) of the susceptible population was infected per outbreak, with >50% of the entire population remaining susceptible at any point. Participants who seroconverted during 2012-2013 were clustered at distances of 350 000 infections were missed by surveillance systems. Serological studies could supplement surveillance to provide important insights on pathogen circulation.

Published
2016

2. High rate of subclinical chikungunya virus infection and association of neutralizing antibody with protection in a prospective cohort in the Philippines

Author

Yoon, In-Kyu, Alera, Maria Theresa, Lago, Catherine B, Tac-An, Ilya A, Villa, Daisy, Fernandez, Stefan, Thaisomboonsuk, Butsaya, Klungthong, Chonticha, Levy, Jens W, Velasco, John Mark, Roque, Vito G, Salje, Henrik, Macareo, Louis R, Hermann, Laura L, Nisalak, Ananda, and Srikiatkhachorn, Anon

Subjects
Adult, Male, Asia, Adolescent, Genotype, Philippines, Enzyme-Linked Immunosorbent Assay, Antibodies, Viral, Cohort Studies, Young Adult, Neutralization Tests, Humans, Longitudinal Studies, Prospective Studies, Child, Asymptomatic Infections, Phylogeny, Base Sequence, Sequence Analysis, RNA, virus diseases, Infant, Middle Aged, Antibodies, Neutralizing, 3. Good health, Caribbean Region, Immunoglobulin M, Child, Preschool, Immunoglobulin G, Chikungunya Fever, Female, Chikungunya virus
Abstract

BACKGROUND: Chikungunya virus (CHIKV) is a globally re-emerging arbovirus for which previous studies have indicated the majority of infections result in symptomatic febrile illness. We sought to characterize the proportion of subclinical and symptomatic CHIKV infections in a prospective cohort study in a country with known CHIKV circulation. METHODS/FINDINGS: A prospective longitudinal cohort of subjects ≥6 months old underwent community-based active surveillance for acute febrile illness in Cebu City, Philippines from 2012-13. Subjects with fever history were clinically evaluated at acute, 2, 5, and 8 day visits, and at a 3-week convalescent visit. Blood was collected at the acute and 3-week convalescent visits. Symptomatic CHIKV infections were identified by positive CHIKV PCR in acute blood samples and/or CHIKV IgM/IgG ELISA seroconversion in paired acute/convalescent samples. Enrollment and 12-month blood samples underwent plaque reduction neutralization test (PRNT) using CHIKV attenuated strain 181/clone25. Subclinical CHIKV infections were identified by ≥8-fold rise from a baseline enrollment PRNT titer 50 years old. Baseline CHIKV PRNT titer ≥10 was associated with 100% (95%CI: 46.1, 100.0) protection from symptomatic CHIKV infection. Phylogenetic analysis demonstrated Asian genotype closely related to strains from Asia and the Caribbean. CONCLUSIONS: Subclinical infections accounted for a majority of total CHIKV infections. A positive baseline CHIKV PRNT titer was associated with protection from symptomatic CHIKV infection. These findings have implications for assessing disease burden, understanding virus transmission, and supporting vaccine development.

3. Reconstruction of 60 Years of Chikungunya Epidemiology in the Philippines Demonstrates Episodic and Focal Transmission

Author

Salje, Henrik, Cauchemez, Simon, Alera, Maria Theresa, Rodriguez-Barraquer, Isabel, Thaisomboonsuk, Butsaya, Srikiatkhachorn, Anon, Lago, Catherine B, Villa, Daisy, Klungthong, Chonticha, Tac-An, Ilya A, Fernandez, Stefan, Velasco, John Mark, Roque, Vito G, Nisalak, Ananda, Macareo, Louis R, Levy, Jens W, Cummings, Derek, and Yoon, In-Kyu

Subjects
Adult, Aged, 80 and over, Male, chikungunya, Adolescent, Philippines, Infant, Newborn, Infant, modeling, History, 20th Century, Middle Aged, History, 21st Century, 3. Good health, serological study, Young Adult, Child, Preschool, Disease Transmission, Infectious, Chikungunya Fever, Cluster Analysis, Humans, epidemiology, Female, Child, Aged
Abstract

Proper understanding of the long-term epidemiology of chikungunya has been hampered by poor surveillance. Outbreak years are unpredictable and cases often misdiagnosed. Here we analyzed age-specific data from 2 serological studies (from 1973 and 2012) in Cebu, Philippines, to reconstruct both the annual probability of infection and population-level immunity over a 60-year period (1952-2012). We also explored whether seroconversions during 2012-2013 were spatially clustered. Our models identified 4 discrete outbreaks separated by an average delay of 17 years. On average, 23% (95% confidence interval [CI], 16%-37%) of the susceptible population was infected per outbreak, with >50% of the entire population remaining susceptible at any point. Participants who seroconverted during 2012-2013 were clustered at distances of 350 000 infections were missed by surveillance systems. Serological studies could supplement surveillance to provide important insights on pathogen circulation.

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