Search

Your search keyword '"L, Skogsberg"' showing total 3 results
Start Over Author "L, Skogsberg" Topic adolescent
3 results on '"L, Skogsberg"'

1. Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk

Author

Sabina, Resic-Lindehammer, K, Larsson, E, Ortqvist, A, Carlsson, E, Cederwall, C M, Cilio, S-A, Ivarsson, B A, Jönsson, H E, Larsson, K, Lynch, J, Neiderud, A, Nilsson, S, Sjöblad, A, Lernmark, M, Aili, L E, Bååth, E, Carlsson, H, Edenwall, G, Forsander, B W, Granstro, I, Gustavsson, R, Hanås, L, Hellenberg, H, Hellgren, E, Holmberg, H, Hörnell, Sten-A, Ivarsson, C, Johansson, G, Jonsell, K, Kockum, B, Lindblad, A, Lindh, J, Ludvigsson, U, Myrdal, K, Segnestam, L, Skogsberg, L, Strömberg, U, Ståhle, B, Thalme, K, Tullus, T, Tuvemo, M, Wallensteen, O, Westphal, and J, Aman

Subjects
Male, Adolescent, Genotype, Endocrinology, Diabetes and Metabolism, Human leukocyte antigen, HLA-DQ alpha-Chains, law.invention, Endocrinology, Gene Frequency, HLA Antigens, law, HLA-DQ Antigens, Diabetes mellitus, HLA-DQ, Internal Medicine, medicine, HLA-DQ beta-Chains, Humans, Age of Onset, Allele, Child, Polymerase chain reaction, Sweden, Autoimmune disease, Type 1 diabetes, business.industry, Infant, General Medicine, medicine.disease, Diabetes Mellitus, Type 1, Child, Preschool, Immunology, Female, business
Abstract

The aim of this study was to compare the frequency of human leukocyte antigen (HLA) genotypes in 1-18-year-old patients with type 1 diabetes newly diagnosed in 1986-1987 (n = 430), 1996-2000 (n = 342) and in 2003-2005 (n = 171). We tested the hypothesis that the HLA DQ genotype distribution changes over time. Swedish type 1 diabetes patients and controls were typed for HLA using polymerase chain reaction amplification and allele specific probes for DQ A1* and B1* alleles. The most common type 1 diabetes HLA DQA1*-B1*genotype 0501-0201/0301-0302 was 36% (153/430) in 1986-1987 and 37% (127/342) in 1996-2000, but decreased to 19% (33/171) in 2003-2005 (P \ 0.0001). The 0501-0201/0501-0201 genotype increased from 1% in 1986-1987 to 7% in 1996-2000 (P = 0.0047) and to 5% in 2003-2005 (P > 0.05). This study in 1-18-year-old Swedish type 1 diabetes patients supports the notion that there is a temporal change in HLA risk.

Published
2008
Full Text
View/download PDF

2. IA-2 autoantibodies in incident type I diabetes patients are associated with a polyadenylation signal polymorphism in GIMAP5

Author

J-H, Shin, M, Janer, B, McNeney, S, Blay, K, Deutsch, C B, Sanjeevi, I, Kockum, A, Lernmark, J, Graham, Hans, Arnqvist, Elizabeth, Björck, Jan, Eriksson, Lennarth, Nyström, Lars Olof, Ohlson, Bengt, Scherstén, Jan, Ostman, M, Aili, L E, Bååth, E, Carlsson, H, Edenwall, G, Forsander, B W, Granström, I, Gustavsson, R, Hanås, L, Hellenberg, H, Hellgren, E, Holmberg, H, Hörnell, Sten-A, Ivarsson, C, Johansson, G, Jonsell, K, Kockum, B, Lindblad, A, Lindh, J, Ludvigsson, U, Myrdal, J, Neiderud, K, Segnestam, S, Sjöblad, L, Skogsberg, L, Strömberg, U, Ståhle, B, Thalme, K, Tullus, T, Tuvemo, M, Wallensteen, O, Westphal, and J, Aman

Subjects
Adult, Male, Adolescent, Immunology, Single-nucleotide polymorphism, Biology, medicine.disease_cause, Polymorphism, Single Nucleotide, Autoimmunity, GTP-Binding Proteins, Diabetes mellitus, Genetics, medicine, Humans, Allele, Child, Genetics (clinical), Autoantibodies, Sweden, Autoantibody, Case-control study, Infant, Newborn, Infant, medicine.disease, Minor allele frequency, Diabetes Mellitus, Type 1, Case-Control Studies, Child, Preschool, Female, Biobreeding rat
Abstract

In a large case-control study of Swedish incident type I diabetes patients and controls, 0-34 years of age, we tested the hypothesis that the GIMAP5 gene, a key genetic factor for lymphopenia in spontaneous BioBreeding rat diabetes, is associated with type I diabetes; with islet autoantibodies in incident type I diabetes patients or with age at clinical onset in incident type I diabetes patients. Initial scans of allelic association were followed by more detailed logistic regression modeling that adjusted for known type I diabetes risk factors and potential confounding variables. The single nucleotide polymorphism (SNP) rs6598, located in a polyadenylation signal of GIMAP5, was associated with the presence of significant levels of IA-2 autoantibodies in the type I diabetes patients. Patients with the minor allele A of rs6598 had an increased prevalence of IA-2 autoantibody levels compared to patients without the minor allele (OR=2.2; Bonferroni-corrected P=0.003), after adjusting for age at clinical onset (P=8.0 x 10(-13)) and the numbers of HLA-DQ A1*0501-B1*0201 haplotypes (P=2.4 x 10(-5)) and DQ A1*0301-B1*0302 haplotypes (P=0.002). GIMAP5 polymorphism was not associated with type I diabetes or with GAD65 or insulin autoantibodies, ICA, or age at clinical onset in patients. These data suggest that the GIMAP5 gene is associated with islet autoimmunity in type I diabetes and add to recent findings implicating the same SNP in another autoimmune disease.

Published
2007

3. SUMO4 M55V polymorphism affects susceptibility to type I diabetes in HLA DR3- and DR4-positive Swedish patients

Author

K Kockum, Gisela Dahlquist, L Hellenberg, Emma Carlsson, Carani B. Sanjeevi, U Ståhle, Ragnar Hanas, U Myrdal, H Hellgren, Gun Forsander, X R Luo, K Tullus, I Gustavsson, Johnny Ludvigsson, G Jonsell, Elizabeth Björck, L E Bååth, Lars Olof Ohlson, Hans J. Arnqvist, Bengt Scherstén, K Segnestam, Torsten Tuvemo, Bengt Lindblad, Jan Östman, Mona Landin-Olsson, Sture Sjöblad, Agne Lindh, Lennarth Nyström, H Hörnell, Sten A. Ivarsson, Åke Lernmark, Calle Johansson, Otto Westphal, M Wallensteen, B W Granström, J. Neiderud, L Skogsberg, B Thalme, Erik Holmberg, H Edenwall, Saikiran K. Sedimbi, M Aili, J Aman, and L Strömberg

Subjects
Adult, Male, Adolescent, Genotype, Immunology, HLA-DR3, Human leukocyte antigen, Biology, Polymorphism, Single Nucleotide, Loss of heterozygosity, Cohort Studies, HLA-DR3 Antigen, Genetics, HLA-DR4 Antigen, Humans, Genetic Predisposition to Disease, Allele, Child, Genetics (clinical), Alleles, Sweden, Infant, Newborn, Infant, Large cohort, Diabetes Mellitus, Type 1, Haplotypes, Relative risk, Case-Control Studies, Child, Preschool, Small Ubiquitin-Related Modifier Proteins, Type i diabetes, Female
Abstract

SUMO4 M55V, located in IDDM5, has been a focus for debate because of its association to type I diabetes (TIDM) in Asians but not in Caucasians. The current study aims to test the significance of M55V association to TIDM in a large cohort of Swedish Caucasians, and to test whether M55V is associated in those carrying human leukocyte antigen (HLA) class II molecules. A total of 673 TIDM patients and 535 age- and sex-matched healthy controls were included in the study. PCR-RFLP was performed to identify the genotype and allele variations. Our data suggest that SUMO4 M55V is not associated with susceptibility to TIDM by itself. When we stratified our patients and controls based on heterozygosity for HLA-DR3/DR4 and SUMO4 genotypes, we found that presence of SUMO4 GG increased further the relative risk conferred by HLA-DR3/DR4 to TIDM, whereas SUMO4 AA decreased the risk. From the current study, we conclude that SUMO4 M55V is associated with TIDM in association with high-risk HLA-DR3 and DR4, but not by itself.

Published
2007

Catalog

Books, media, physical & digital resources
See catalog results