8 results on '"Hong, Hyun Ju"'
Search Results
2. Suicide warning signs that are challenging to recognize: a psychological autopsy study of Korean adolescents
- Author
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Lee, Yeon Jung, Kweon, Yong-Sil, Kang, Yun Hyong, Yoon, Kyung Hee, Lee, Mi-Sun, Bhang, Soo-Young, and Hong, Hyun Ju
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- 2024
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- View/download PDF
3. Investigation of previously implicated genetic variants in chronic tic disorders: a transmission disequilibrium test approach
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Abdulkadir, Mohamed, Londono, Douglas, Gordon, Derek, Fernandez, Thomas V, Brown, Lawrence W, Cheon, Keun-Ah, Coffey, Barbara J, Elzerman, Lonneke, Fremer, Carolin, Fründt, Odette, Garcia-Delgar, Blanca, Gilbert, Donald L, Grice, Dorothy E, Hedderly, Tammy, Heyman, Isobel, Hong, Hyun Ju, Huyser, Chaim, Ibanez-Gomez, Laura, Jakubovski, Ewgeni, Kim, Young Key, Kim, Young Shin, Koh, Yun-Joo, Kook, Sodahm, Kuperman, Samuel, Leventhal, Bennett, Ludolph, Andrea G, Madruga-Garrido, Marcos, Maras, Athanasios, Mir, Pablo, Morer, Astrid, Müller-Vahl, Kirsten, Münchau, Alexander, Murphy, Tara L, Plessen, Kerstin J, Roessner, Veit, Shin, Eun-Young, Song, Dong-Ho, Song, Jungeun, Tübing, Jennifer, van den Ban, Els, Visscher, Frank, Wanderer, Sina, Woods, Martin, Zinner, Samuel H, King, Robert A, Tischfield, Jay A, Heiman, Gary A, Hoekstra, Pieter J, and Dietrich, Andrea
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Biomedical and Clinical Sciences ,Biological Psychology ,Clinical Sciences ,Neurosciences ,Psychology ,Brain Disorders ,Autism ,Genetics ,Pediatric ,Mental Health ,Intellectual and Developmental Disabilities (IDD) ,Tourette Syndrome ,Neurodegenerative ,Human Genome ,2.1 Biological and endogenous factors ,Aetiology ,Mental health ,Adolescent ,Adult ,Child ,Child ,Preschool ,Family Health ,Female ,Genome-Wide Association Study ,Genotype ,Humans ,Linkage Disequilibrium ,Male ,Microtubule-Associated Proteins ,Middle Aged ,Polymorphism ,Single Nucleotide ,Severity of Illness Index ,Tic Disorders ,Tryptophan Hydroxylase ,Young Adult ,Attention-deficit/hyperactivity disorder ,Candidate gene study ,Obsessive-compulsive disorder ,Tourette syndrome ,Transmission Disequilibrium Test ,Obsessive–compulsive disorder ,Cognitive Sciences ,Psychiatry ,Clinical sciences ,Biological psychology - Abstract
Genetic studies in Tourette syndrome (TS) are characterized by scattered and poorly replicated findings. We aimed to replicate findings from candidate gene and genome-wide association studies (GWAS). Our cohort included 465 probands with chronic tic disorder (93% TS) and both parents from 412 families (some probands were siblings). We assessed 75 single nucleotide polymorphisms (SNPs) in 465 parent-child trios; 117 additional SNPs in 211 trios; and 4 additional SNPs in 254 trios. We performed SNP and gene-based transmission disequilibrium tests and compared nominally significant SNP results with those from a large independent case-control cohort. After quality control 71 SNPs were available in 371 trios; 112 SNPs in 179 trios; and 3 SNPs in 192 trios. 17 were candidate SNPs implicated in TS and 2 were implicated in obsessive-compulsive disorder (OCD) or autism spectrum disorder (ASD); 142 were tagging SNPs from eight monoamine neurotransmitter-related genes (including dopamine and serotonin); 10 were top SNPs from TS GWAS; and 13 top SNPs from attention-deficit/hyperactivity disorder, OCD, or ASD GWAS. None of the SNPs or genes reached significance after adjustment for multiple testing. We observed nominal significance for the candidate SNPs rs3744161 (TBCD) and rs4565946 (TPH2) and for five tagging SNPs; none of these showed significance in the independent cohort. Also, SLC1A1 in our gene-based analysis and two TS GWAS SNPs showed nominal significance, rs11603305 (intergenic) and rs621942 (PICALM). We found no convincing support for previously implicated genetic polymorphisms. Targeted re-sequencing should fully appreciate the relevance of candidate genes.
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- 2018
4. Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder
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Abdulkadir, Mohamed, Tischfield, Jay A, King, Robert A, Fernandez, Thomas V, Brown, Lawrence W, Cheon, Keun-Ah, Coffey, Barbara J, de Bruijn, Sebastian FTM, Elzerman, Lonneke, Garcia-Delgar, Blanca, Gilbert, Donald L, Grice, Dorothy E, Hagstrøm, Julie, Hedderly, Tammy, Heyman, Isobel, Hong, Hyun Ju, Huyser, Chaim, Ibanez-Gomez, Laura, Kim, Young Key, Kim, Young-Shin, Koh, Yun-Joo, Kook, Sodahm, Kuperman, Samuel, Lamerz, Andreas, Leventhal, Bennett, Ludolph, Andrea G, Madruga-Garrido, Marcos, Maras, Athanasios, Messchendorp, Marieke D, Mir, Pablo, Morer, Astrid, Münchau, Alexander, Murphy, Tara L, Openneer, Thaïra JC, Plessen, Kerstin J, Rath, Judith JG, Roessner, Veit, Fründt, Odette, Shin, Eun-Young, Sival, Deborah A, Song, Dong-Ho, Song, Jungeun, Stolte, Anne-Marie, Tübing, Jennifer, van den Ban, Els, Visscher, Frank, Wanderer, Sina, Woods, Martin, Zinner, Samuel H, State, Matthew W, Heiman, Gary A, Hoekstra, Pieter J, and Dietrich, Andrea
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Clinical and Health Psychology ,Biomedical and Clinical Sciences ,Psychology ,Mental Health ,Tourette Syndrome ,Neurosciences ,Neurodegenerative ,Pediatric ,Clinical Research ,Attention Deficit Hyperactivity Disorder (ADHD) ,Infant Mortality ,Serious Mental Illness ,Perinatal Period - Conditions Originating in Perinatal Period ,Preterm ,Low Birth Weight and Health of the Newborn ,Brain Disorders ,Aetiology ,2.1 Biological and endogenous factors ,Mental health ,Good Health and Well Being ,Adolescent ,Adult ,Age Factors ,Aged ,Aged ,80 and over ,Attention Deficit Disorder with Hyperactivity ,Case-Control Studies ,Child ,Child ,Preschool ,Europe ,Female ,Humans ,Male ,Middle Aged ,Obsessive-Compulsive Disorder ,Parent-Child Relations ,Pregnancy ,Pregnancy Complications ,Psychiatric Status Rating Scales ,Republic of Korea ,Retrospective Studies ,Severity of Illness Index ,Sex Factors ,Tic Disorders ,United States ,Young Adult ,Attention-deficit hyperactivity disorder ,Delivery ,Obsessive-compulsive disorder ,Prenatal ,Tourette syndrome ,Medical and Health Sciences ,Psychology and Cognitive Sciences ,Psychiatry ,Clinical sciences ,Clinical and health psychology - Abstract
Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study. This study included 586 participants with a chronic tic disorder and 527 unaffected family controls. We controlled for age and sex differences by creating propensity score matched subsamples for both case-control and within-case analyses. We found that premature birth (OR = 1.72) and morning sickness requiring medical attention (OR = 2.57) were associated with the presence of a chronic tic disorder. Also, the total number of pre- and perinatal complications was higher in those with a tic disorder (OR = 1.07). Furthermore, neonatal complications were related to the presence (OR = 1.46) and severity (b = 2.27) of co-occurring OCD and also to ADHD severity (b = 1.09). Delivery complications were only related to co-occurring OCD (OR = 1.49). We conclude that early exposure to adverse situations during pregnancy is related to the presence of chronic tic disorders. Exposure at a later stage, at birth or during the first weeks of life, appears to be associated with co-occurring OCD and ADHD.
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- 2016
5. The impact of psychological problems and adverse life events on suicidal ideation among adolescents using nationwide data of a school-based mental health screening test in Korea
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Lee, Dayoung, Jung, Song, Park, Seongjun, and Hong, Hyun Ju
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- 2018
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6. Gender differences in Korean adolescents who died by suicide based on teacher reports
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Jung, Song, Lee, Dayoung, Park, Sungjun, Lee, Kangwoo, Kweon, Yong-Sil, Lee, Eun-Jin, Yoon, Kyung Hee, Cho, Hannah, Jung, Hyeji, Kim, Ah Reum, Shin, Bo-Ram, and Hong, Hyun Ju
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- 2019
- Full Text
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7. Suicide warning signs that are challenging to recognize: a psychological autopsy study of Korean adolescents.
- Author
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Lee, Yeon Jung, Kweon, Yong-Sil, Kang, Yun Hyong, Yoon, Kyung Hee, Lee, Mi-Sun, Bhang, Soo-Young, and Hong, Hyun Ju
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SUICIDE risk factors ,PSYCHIATRIC diagnosis ,AUTOPSY ,QUALITATIVE research ,RESEARCH funding ,QUESTIONNAIRES ,FAMILY history (Medicine) ,RETROSPECTIVE studies ,QUANTITATIVE research ,DESCRIPTIVE statistics ,TEENAGERS' conduct of life ,SUICIDE ,PERSONALITY ,RESEARCH methodology ,ADOLESCENCE - Abstract
Background: In South Korea, the leading cause of youth death has been suicide for about 20 years. In this study, we conducted a multi-method psychological autopsy to identify the psychiatric diagnosis, developmental history, personality traits, family history, school life, warning signs of suicide, and risk factors related to suicide for the first time in Korea. Methods: This was a postmortem, retrospective, and descriptive study of 36 adolescents who died by suicide between August 2015 and July 2021 in South Korea. We obtained qualitative and quantitative data from the Korean Psychological Autopsy of Adolescent, conducted by the Suicide and School Mental Health Institute, the official student mental health policy-focused research institute of the Korean Ministry of Education. Results: The adolescents comprised equal percentage of girls and boys. Approximately half of the deaths (55.6%) occurred at home and most (72.2%) involved jumping from a height. Most of the adolescents (97.2%) had one major psychiatric disorder before death, with depressive disorder being the most prevalent (75%). They were at a high risk for internet addiction before death. The most common personality trait was avoidance (28.6%), followed by submissiveness (27.3%). Half of the parents reported that the adolescents were satisfied with their school life and the teachers observed that they had no behavioral problems. One year before death, seven (19.4%) adolescents injured themselves and five (13.9%) had attempted suicide. Most of the deceased (80.6%) had expressed suicide warning signs to their families within one year before death. Adolescents had a long experience of family-related adverse events. Conclusions: Most of the adolescents had mental health disorders and expressed suicidal intentions using verbal and nonverbal signs. However, it was challenging for families to recognize the risk signs because of adolescents' personality traits or a good school life. To prevent adolescent suicide, adolescents, parents, and teachers need to be educated to recognize signs of suicide warning signs and equipped to guide adolescents to appropriate care. [ABSTRACT FROM AUTHOR]
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- 2023
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- View/download PDF
8. Subtypes of suicidal ideation in Korean adolescents: A multilevel latent profile analysis.
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Jung, Song, Lee, Dayoung, Park, Seongjun, and Hong, Hyun Ju
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PSYCHIATRIC diagnosis ,COMPETENCY assessment (Law) ,AFFECTIVE disorders ,BEHAVIOR disorders in children ,BUDGET ,CONFLICT (Psychology) ,MENTAL depression ,SCHOOL dropouts ,MEDICAL screening ,MENTAL health services ,PUBLIC welfare ,SEX distribution ,TEENAGERS' conduct of life ,AFFINITY groups ,FAMILY conflict ,SOCIOECONOMIC factors ,STRUCTURAL equation modeling ,SUICIDAL ideation ,PSYCHOLOGICAL factors - Abstract
Objective: This study intended to classify subtypes of Korean adolescents with suicidal ideation based on mental health problems and to explore the relationship between such subtypes and individual-, school- and community-level factors. Method: Data from high school freshmen who participated in the 2013 school-based mental health screening test and data about school and community variables obtained from public sources were combined and analyzed. A multilevel latent profile analysis using mental health issues as class indicators that included several predictors was conducted. Results: Three latent profiles were identified: Group 1 (6.5%) had high scores for both the internalizing and externalizing problems; Group 2 (40.2%) had high scores for internalizing problems, such as depression and mood related symptoms; and Group 3 (53.3%) had lower scores for all mental health problems compared to Groups 1 and 2. Gender, peer conflict, family conflict and academic problems were significant predictors at the individual level; school dropout rate was a significant school-level variable; and percent of youth in the total population, availability of mental health services, number of social welfare facilities and percentage of the total budget devoted to education/welfare were significant community-level variables. Conclusion: The present findings suggest that adolescents with suicidal ideation can be classified into several distinct subtypes based on mental health problems. These profiles and their associated covariates will aid in the establishment of youth suicide prevention policies. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
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