1. Fungal infections in hematopoietic stem cell transplantation in children at a pediatric children’s hospital in Argentina
- Author
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Alicira Fynn, Lillian Sung, Fernanda Sosa, Cecilia Vescina, Claudia Ruiz, Sergio Gomez, Miguela A. Caniza, and Daniela Iglesias
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Antifungal Agents ,Adolescent ,medicine.medical_treatment ,030106 microbiology ,Argentina ,Graft vs Host Disease ,Hematopoietic stem cell transplantation ,Single Center ,Immunocompromised Host ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Yeasts ,Internal medicine ,medicine ,Humans ,In patient ,Child ,Retrospective Studies ,Immunosuppression Therapy ,Transplantation ,business.industry ,Incidence ,Incidence (epidemiology) ,Hematopoietic Stem Cell Transplantation ,Infant ,Autologous hsct ,Retrospective cohort study ,Antibiotic Prophylaxis ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,Survival Rate ,Treatment Outcome ,surgical procedures, operative ,Infectious Diseases ,Child, Preschool ,030220 oncology & carcinogenesis ,Allogeneic hsct ,Female ,Complication ,business ,Invasive Fungal Infections ,Follow-Up Studies - Abstract
Our primary objective was to describe the incidence of proven or probable invasive fungal infections (IFIs), a devastating complication of hematopoietic stem cell transplant (HSCT), in HCST in a middle-income country. Secondary objectives were to describe factors associated with IFIs and outcomes. In this single center retrospective study, pediatric patients who underwent a first allogeneic or autologous HSCT from 1998 to 2016 were included. Of the 251 HSCT recipients: 143 transplants were allogeneic and 108 were autologous. Overall, 23 (9%) experienced an IFI, mostly due to yeasts (83%). IFIs were more common in allogeneic HSCT (18/143, 13%) than in autologous HSCT (5/108, 5%; P = .045). Of the 23 patients with IFIs, 14 (61%) died, but only 1 directly from IFI (pulmonary aspergillosis). Overall survival at 3 years was 0.42 ± 0.11 in patients with IFIs and 0.60 ± 0.37 in those without IFIs (P = .049). In Argentina, IFIs during HSCT are common. Recipients of allogeneic HSCT are at higher risk, and IFI is associated with reduced overall survival. Future work should focus on interventions to reduce and improve IFI outcomes in children undergoing transplants in low- and middle-income countries.
- Published
- 2018