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In the last few years, a great effort has been made with the aim of discovering cervical cancer etiology factor(s). At present, both HSV and HPV have been demonstrated strictly associated with cervical premalignant and malignant lesions. Nevertheless problems do exist in achieving the definitive evidence of a causative role exerted by herpes virus and/or by papilloma virus. Starting from 1984, our group studied the humoral immune response against herpes virus type two, in patients affected with CIN and invasive cervical cancer, as well as with atypical metaplasia and papilloma virus cytopathic effect at pap test, giving in 1985, the first evidence that serum levels of specific anti-herpes IgA strictly correlates both with infections and viral shedding, even when asymptomatic, as with various stages in cervical oncogenesis. This study updates our previous reports showing that IgA serum levels may be a useful marker in herpes related human diseases. Finally, data show the preliminary evidence that IgA, when levels are determined in the male partners of patients, is also useful in the screening and detection of "high risk males". These data, if further confirmed, will be of great advantage in the clinical monitoring of cervical cancer treatments, as well as in management and follow-up of preinvasive epithelial lesions of the cervix.