1. Early increases in concentrations of total, LDL, and HDL cholesterol in HIV-infected children following new exposure to antiretroviral therapy
- Author
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Marc D Foca, Kevin A. Sztam, Richard J. Deckelbaum, Andrea Jurgrau, and Hongyu Jiang
- Subjects
Male ,Time Factors ,Adolescent ,HIV Infections ,chemistry.chemical_compound ,Acquired immunodeficiency syndrome (AIDS) ,Risk Factors ,Immunopathology ,Medicine ,Humans ,Sida ,Child ,Dyslipidemias ,biology ,business.industry ,Cholesterol ,Cholesterol, HDL ,Gastroenterology ,Infant, Newborn ,nutritional and metabolic diseases ,Infant ,Cholesterol, LDL ,biology.organism_classification ,medicine.disease ,chemistry ,Anti-Retroviral Agents ,Cardiovascular Diseases ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Immunology ,Lentivirus ,Female ,Viral disease ,business ,Dyslipidemia ,Lipoprotein - Abstract
Antiretroviral therapy (ART) is associated with dyslipidemia and cardiovascular disease in adults infected with HIV. For children perinatally infected with HIV, ART exposure is lifelong and early-onset dyslipidemia could have significant long-term effects. We examined cholesterol levels in children during the first year after exposure to a new ART regimen (initiation or switch). In 52 children, total cholesterol increased by 30.5 and 43 mg/dL at 6 and 12 months, respectively (P0.001). Low-density lipoprotein cholesterol made the largest contribution, but high-density lipoprotein cholesterol also increased within months of therapy alteration. Early identification of these children and intervention could mediate potential increased risk for future cardiovascular disease.
- Published
- 2011