1. Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey
- Author
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Ömer Tarım, Aylin Kılınç Uğurlu, Hüseyin Anıl Korkmaz, Serap Turan, Emine Demet Akbaş, Esra Döğer, Zeynep Atay, Sezer Acar, Mehmet Emre Atabek, Serpil Bas, Ayhan Abaci, Ayça Törel Ergür, Melek Yildiz, Halil Saglam, Oya Ercan, Tulay Guran, Eda Celebi Bitkin, Ulku Gul, Zeynep Şıklar, Merih Berberoğlu, Eda Mengen Uçaktürk, Abdullah Bereket, Edip Unal, Elif Söbü, Firdevs Bas, Servet Yel, Ayşehan Akıncı, Enver Simsek, Erdal Eren, Şükriye Pınar İşgüven, OMÜ, Kırıkkale Üniversitesi, Eren, Erdal, Ergur, Ayca Torel, Isguven, Sukriye Pinar, Bitkin, Eda Celebi, Berberoglu, Merih, Siklar, Zeynep, Bas, Firdevs, Yel, Servet, Bas, Serpil, Sobu, Elif, Bereket, Abdullah, Turan, Serap, Saglam, Halil, Atay, Zeynep, Ercan, Oya, Guran, Tulay, Atabek, Mehmet Emre, Korkmaz, Huseyin Anil, Ugurlu, Aylin Kilinc, Akinci, Aysehan, Doger, Esra, Simsek, Enver, Akbas, Emine Demet, Abaci, Ayhan, Gul, Ulku, Acar, Sezer, Ucakturk, Eda Mengen, Yildiz, Melek, Unal, Edip, Tarim, Omer, İÜC, Cerrahpaşa Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Eren, E, Ergur, AT, Isguven, SP, Bitkin, EC, Berberoglu, M, Siklar, Z, Bas, F, Yel, S, Bas, S, Sobu, E, Bereket, A, Turan, S, Saglam, H, Atay, Z, Ercan, O, Guran, T, Atabek, ME, Korkmaz, HA, Ugurlu, AK, Akinci, A, Doger, E, Simsek, E, Akbas, ED, Abaci, A, Gul, U, Acar, S, Ucakturk, EM, Yildiz, M, Unal, E, Tarim, O, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, İşgüven, Şükriye Pınar, and Çukurova Üniversitesi
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Male ,Pediatrics ,Turkey ,Endocrinology, Diabetes and Metabolism ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,surgery ,0302 clinical medicine ,Endocrinology ,Surveys and Questionnaires ,030212 general & internal medicine ,Child ,microadenomas ,lcsh:RJ1-570 ,Prognosis ,Gynecomastia ,Child, Preschool ,OBESITY ,Cohort ,cabergoline ,Female ,Original Article ,macroadenomas ,medicine.symptom ,Headaches ,medicine.drug ,Adenoma ,Galactorrhea ,medicine.medical_specialty ,prolactin ,Adolescent ,030209 endocrinology & metabolism ,Short stature ,03 medical and health sciences ,children ,Cabergoline ,medicine ,Humans ,Retrospective Studies ,lcsh:RC648-665 ,business.industry ,Infant ,lcsh:Pediatrics ,medicine.disease ,PROLACTIN RECEPTOR ,Bromocriptine ,Hyperprolactinemia ,Pituitary ,Pediatrics, Perinatology and Child Health ,Etiology ,business ,MACROPROLACTINOMAS ,Biomarkers ,Follow-Up Studies - Abstract
siklar, zeynep/0000-0003-0921-2694; Eren, Erdal/0000-0002-1684-1053; Turan, Serap/0000-0002-5172-5402; Bas, Firdevs/0000-0001-9689-4464; Ercan, Oya/0000-0001-7397-2837; Bas, Serpil/0000-0001-6210-4807; berberoglu, merih/0000-0003-3102-0242; Torel Ergur, Ayca/0000-0002-7792-1727; Yel, Servet/0000-0001-6889-4504; Mengen, Eda/0000-0003-1597-8418 WOS:000469271100006 PubMed ID: 30396878 Objective: We aimed to report the characteristics at admission, diagnosis, treatment, and follow-up of cases of pediatric hyperprolactinemia in a large multicenter study. Methods: We reviewed the records of 233 hyperprolactinemic patients, under 18 years of age, who were followed by different centers. The patients were divided as having microadenomas, macroadenomas, drug-induced hyperprolactinemia and idiopathic hyperprolactinemia. Complaints of the patients, their mode of treatment (medication and/or surgery) and outcomes were evaluated in detail. Results: The mean age of the patients with hyperprolactinemia was 14.5 years, and 88.4% were females. In terms of etiology, microadenomas were observed in 32.6 %, macroadenomas in 27 %, idiopathic hyperprolactinemia in 22.7% and drug-induced hyperprolactinemia in 6.4 %. Other causes of hyperprolactinemia were defined in 11.3%. Common complaints in females (n = 206) were sorted into menstrual irregularities, headaches, galactorrhea, primary or secondary amenorrhea and weight gain, whereas headache, gynecomastia, short stature and blurred vision were common in males (n = 27). Median prolactin levels were 93.15 ng/mL, 241.8 ng/ml, 74.5 ng/mL, 93.2 ng/mL, and 69 ng/mL for microadenomas, macroadenomas, idiopathic hyperprolactinemia, drug-induced hyperprolactinemia, and other causes of hyperprolactinemia, respectively. Of 172 patients with hyperprolactinemia, 77.3 % were treated with cabergoline and 13.4 % with bromocriptine. 20.1 % of the patients with pituitary adenomas underwent pituitary surgery. Conclusion: We present the largest cohort of children and adolescents with hyperprolactinemia in the literature to date. Hyperprolactinemia is more common in females and cabergoline is highly effective and practical to use in adolescents, due to its biweekly dosing. Indications for surgery in pediatric cases need to be revised. Turkish Pediatric Endocrinology and Diabetes Society [2015-1136]; National Pediatric Endocrinology Society This work was supported by a grant from the Turkish Pediatric Endocrinology and Diabetes Society (2015-1136). The authors would like to thank the National Pediatric Endocrinology Society for financial and technical support for the paper.
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- 2019