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1. Pulmonary Mycobacterium bovis BCG Vaccination Confers Dose-Dependent Superior Protection Compared to That of Subcutaneous Vaccination

Author

Eamonn Gormley, Joaquin Rullas-Trincado, Esther Pérez-Herrán, Eva Maria Lopez-Roman, Nacho Aguilo, Ana Maria Toledo, Carlos Martin, and Iñigo Angulo-Barturen

Subjects
Microbiology (medical), Injections, Subcutaneous, Clinical Biochemistry, Immunology, Dose dependence, Colony Count, Microbial, Spleen, Mycobacterium tuberculosis, Pulmonary tuberculosis, Administration, Inhalation, medicine, Immunology and Allergy, Animals, Lung, Tuberculosis, Pulmonary, Mycobacterium bovis, Vaccines, biology, business.industry, Vaccination, biology.organism_classification, Virology, 3. Good health, Mice, Inbred C57BL, Disease Models, Animal, medicine.anatomical_structure, BCG Vaccine, business, BCG vaccine
Abstract

Worldwide, the Mycobacterium bovis BCG vaccine is one of the most widely used vaccines. However, it appears to be ineffective in preventing pulmonary tuberculosis. Here, we show that pulmonary BCG vaccination of mice with a broad dose range provides superior protection against Mycobacterium tuberculosis challenge compared to that of subcutaneous vaccination.

Published
2014
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