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Your search keyword '"Laudadio, Lucio"' showing total 2 results
Start Over Author "Laudadio, Lucio" Topic adjuvant therapy
2 results on '"Laudadio, Lucio"'

1. Demographic, tumor and clinical features of clinical trials versus clinical practice patients with HER2-positive early breast cancer: results of a prospective study

Author

Arpino, Grazia, Michelotti, Andrea, Truini, Mauro, Montemurro, Filippo, Russo, Stefania, Palumbo, Raffaella, Zamagni, Claudio, Latorre, Agnese, Bruzzese, Dario, Riccardi, Ferdinando, De Laurentiis, Michelino, Beano, Alessandra, Biganzoli, Laura, Zaniboni, Alberto, Laudadio, Lucio, Malagoli, Maria, Bilancia, Domenico, Schettini, Francesco, Giuliano, Mario, Cazzaniga, Marina Elena, and De Placido, Sabino

Published
2016
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2. Demographic, tumor and clinical features of clinical trials versus clinical practice patients with HER2-positive early breast cancer: results of a prospective study

Author

Grazia Arpino, Claudio Zamagni, Ferdinando Riccardi, Laura Biganzoli, Mario Giuliano, Alessandra Beano, Michelino De Laurentiis, Lucio Laudadio, Sabino De Placido, Dario Bruzzese, Andrea Michelotti, Stefania Russo, Francesco Schettini, Domenico Bilancia, Alberto Zaniboni, Mauro Truini, Marina Cazzaniga, Maria Malagoli, Filippo Montemurro, Raffaella Palumbo, A. Latorre, Arpino, Grazia, Michelotti, Andrea, Truini, Mauro, Montemurro, Filippo, Russo, Stefania, Palumbo, Raffaella, Zamagni, Claudio, Latorre, Agnese, Bruzzese, Dario, Riccardi, Ferdinando, DE LAURENTIIS, Michelino, Beano, Alessandra, Biganzoli, Laura, Zaniboni, Alberto, Laudadio, Lucio, Malagoli, Maria, Bilancia, Domenico, Schettini, Francesco, Giuliano, Mario, Cazzaniga, Marina Elena, DE PLACIDO, Sabino, Arpino, G, Michelotti, A, Truini, M, Montemurro, F, Russo, S, Palumbo, R, Zamagni, C, Latorre, A, Bruzzese, D, Riccardi, F, De Laurentiis, M, Beano, A, Biganzoli, L, Zaniboni, A, Laudadio, L, Malagoli, M, Bilancia, D, Schettini, F, Giuliano, M, Cazzaniga, M, and De Placido, S

Subjects
Adult, Oncology, Cancer Research, medicine.medical_specialty, Receptor, ErbB-2, Breast Neoplasms, Clinical practice, Adjuvant therapy, law.invention, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Meta-Analysis as Topic, Randomized controlled trial, law, Trastuzumab, Internal medicine, HER2, medicine, Humans, 030212 general & internal medicine, Practice Patterns, Physicians', skin and connective tissue diseases, Prospective cohort study, neoplasms, Aged, Randomized Controlled Trials as Topic, Aged, 80 and over, clinical trials, clinical practice, early breast cancer, Hematology, business.industry, Early breast cancer, General Medicine, Middle Aged, medicine.disease, Clinical Practice, Clinical trial, Italy, 030220 oncology & carcinogenesis, Physical therapy, Female, business, medicine.drug
Abstract

Background: Several randomized clinical trials (RCTs) have demonstrated the efficacy of trastuzumab-based adjuvant therapy in HER2-positive breast cancer (BC). However, RCT patients may not invariably be representative of patients routinely seen in clinical practice (CP). To address this issue, we compared the clinical and tumor features of RCT and CP patients with HER2-positive BC. Patients and methods: From January to December 2012, 650 consecutive patients with HER2-positive early BC, treated in 36 different types of Italian healthcare facilities, were enrolled in this study. Age, treatment, tumor size (T), nodes (N), grade (G), estrogen receptor (ER) and progesterone receptor (PgR) status were prospectively collected in these CP patients. The same data were extracted from the main adjuvant trastuzumab RCTs and pooled using the random-effects model of DerSimonian and Laird. RCT and CP patients were compared by using the Cochran Q statistics. Results: Versus RCT patients, CP patients were more likely to be older than 50years (65 vs. 49%; p2cm (T≥2cm 39 vs. 59%; p&nbsp

Published
2016

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