1. Gut microbiota from twins discordant for obesity modulate metabolism in mice.
- Author
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Ridaura VK, Faith JJ, Rey FE, Cheng J, Duncan AE, Kau AL, Griffin NW, Lombard V, Henrissat B, Bain JR, Muehlbauer MJ, Ilkayeva O, Semenkovich CF, Funai K, Hayashi DK, Lyle BJ, Martini MC, Ursell LK, Clemente JC, Van Treuren W, Walters WA, Knight R, Newgard CB, Heath AC, and Gordon JI
- Subjects
- Adult, Animals, Bacteroidetes genetics, Cecum metabolism, Cecum microbiology, Diet, Fat-Restricted, Feces microbiology, Female, Germ-Free Life, Humans, Metabolome, Metagenome genetics, Mice, Mice, Inbred C57BL, Mice, Obese, Obesity genetics, Thinness microbiology, Twins, Weight Gain, Young Adult, Adiposity, Bacteroidetes physiology, Gastrointestinal Tract microbiology, Metagenome physiology, Obesity metabolism
- Abstract
The role of specific gut microbes in shaping body composition remains unclear. We transplanted fecal microbiota from adult female twin pairs discordant for obesity into germ-free mice fed low-fat mouse chow, as well as diets representing different levels of saturated fat and fruit and vegetable consumption typical of the U.S. diet. Increased total body and fat mass, as well as obesity-associated metabolic phenotypes, were transmissible with uncultured fecal communities and with their corresponding fecal bacterial culture collections. Cohousing mice harboring an obese twin's microbiota (Ob) with mice containing the lean co-twin's microbiota (Ln) prevented the development of increased body mass and obesity-associated metabolic phenotypes in Ob cage mates. Rescue correlated with invasion of specific members of Bacteroidetes from the Ln microbiota into Ob microbiota and was diet-dependent. These findings reveal transmissible, rapid, and modifiable effects of diet-by-microbiota interactions.
- Published
- 2013
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