1. Pathological characteristics of breast nodules after large‐volume fat grafting for breast augmentation.
- Author
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Li, Yibao, Yao, Yao, Li, Jian, He, Yunfan, Xu, Mimi, Liu, Kaiyang, You, Xin, Chen, Kaiqi, Lu, Feng, Gao, Jianhua, and Liao, Yunjun
- Subjects
BREAST biopsy ,FAT ,ADIPOSE tissues ,BLOOD vessels ,DRUG target - Abstract
Background: The complications of large‐volume fat grafting (LVFG) for breast augmentation remain unpredictable and include palpable breast nodules, oil cysts, and calcifications. Aims: This study was aimed to provide an optimal treatment option for breast nodules after LVFG and evaluate their pathological characteristics. Patients/Methods: We effectively performed complete resection of breast nodules in 29 patients after LVFG using a minimal skin incision with the vacuum‐assisted breast biopsy (VABB) system under ultrasound guidance. And we further carried on histologic examination of excised nodules and evaluated their pathological characteristics. Results: The breast nodules were excised thoroughly with cosmetic effect satisfactorily. Interestingly, subsequent histologic examination showed that type I and VI collagens were strongly expressed in the fibrotic area and type IV collagen were positively expressed around the blood vessel. Furthermore, we found that the type VI collagen+ area appeared around mac2+ macrophages and α‐SMA+ myofibroblasts. Conclusions: The VABB system may be the optimal treatment option for breast nodules after LVFG. And type VI collagens may serve as a biomarker of grafted adipose tissue fibrosis. The relationship between macrophages, fibroblasts, and collagen formation may be therapeutic targets for regulating fibrosis. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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