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Your search keyword '"Lacorte, Jean-Marc"' showing total 5 results
Start Over Author "Lacorte, Jean-Marc" Topic adiponectin
5 results on '"Lacorte, Jean-Marc"'

1. [Mutltifaceted biological roles of adiponectin].

Author

Cuerq C, Morineau G, Dufour-Rainfray D, Vatier C, Fellahi S, Vigouroux C, Genoux A, Lacorte JM, Charchour R, Fève B, Capeau J, Collet C, and Bastard JP

Subjects
Animals, Cognition Disorders etiology, Cognition Disorders metabolism, Cognition Disorders pathology, Diabetes Mellitus, Type 2 etiology, Diabetes Mellitus, Type 2 metabolism, Diabetes Mellitus, Type 2 pathology, Fatty Liver etiology, Fatty Liver metabolism, Humans, Insulin metabolism, Insulin Resistance physiology, Metabolic Syndrome etiology, Metabolic Syndrome metabolism, Metabolic Syndrome pathology, Neoplasms etiology, Neoplasms metabolism, Neoplasms pathology, Obesity metabolism, Obesity pathology, Obesity physiopathology, Adiponectin physiology
Abstract

Adiponectin is a major adipokine involved in energy homeostasis that exerts insulin-sensitizing properties. The level of adiponectin is reduced in situations of insulin resistance and is negatively associated with several pathophysiological situations including abdominal obesity, metabolic syndrome, steatosis and non-alcoholic steatohepatitis, type 2 diabetes, some cancers and cognitive diseases. These aspects are discussed in this review.

Published
2020
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2. Serum concentration and vascular expression of adiponectin are differentially associated with the diabetic calcifying peripheral arteriopathy

Author

Aubert, Carole E., Liabeuf, Sophie, Amouyal, Chloé, Kemel, Salim, Lajat-Kiss, Frédérique, Lacorte, Jean-Marc, Halbron, Marine, Carlier, Aurélie, Salem, Joe-Elie, Funck-Brentano, Christian, Perisic Matic, Ljubica, Witasp, Anna, Stenvinkel, Peter, Phan, Franck, Massy, Ziad A., Hartemann, Agnès, and Bourron, Olivier

Published
2019
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3. Leptin, adiponectin, lipodystrophic and severe insulin resistance syndromes

Author

Vatier, Camille, Jéru, Isabelle, Fellahi, Soraya, Capeau, Jacqueline, Bastard, Jean-Philippe, Vigouroux, Corinne, Charchour, Rim, Collet, Christine, CUERQ, Charlotte, Dufour-Rainfray, Diane, Genoux, Annelise, Guibourdenche, Jean, Lacorte, Jean-Marc, Morineau, Gilles, Centre de Recherche Saint-Antoine (CR Saint-Antoine), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service d'Endocrinologie, diabétologie et endocrinologie de la reproduction [CHU Saint-Antoine], CHU Saint-Antoine [AP-HP], Laboratoire commun de biologie et génétique moléculaires [CHU Saint-Antoine], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service de biochimie et hormonologie [CHU Tenon], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Tenon [AP-HP], and CHU Henri Mondor

Subjects
adiponectin, insulin resistance, lipodystrophies, metreleptine, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, leptin
Abstract

International audience; Leptin and adiponectin are two adipokines currently used as biomarkers for diagnostic orientation and phenotyping in syndromes of lipodystrophy and severe insulin resistance. The level of these biomarkers also has an impact on the therapeutic management of the patients. These aspects, as well as our experience as a reference center, are described in this brief overview.; La leptine et l’adiponectine sont deux adipokines actuellement utilisées comme biomarqueurs d’orientation diagnostique et de phénotypage dans les syndromes lipodystrophiques et les syndromes d’insulino-résistance sévère. Les valeurs de ces biomarqueurs ont également un impact sur la prise en charge thérapeutique des patients. Ces aspects, ainsi que notre expérience comme centre référent national, sont décrits dans cette brève mise au point.

Published
2020

5. Ghrelin, adipokines, metabolic factors in relation with weight status in school-children and results of a 1-year lifestyle intervention program.

Author

Rambhojan, Christine, Bouaziz-Amar, Elodie, Larifla, Laurent, Deloumeaux, Jacqueline, Clepier, Josiane, Plumasseau, Jean, Lacorte, Jean-Marc, and Foucan, Lydia

Subjects
BLOOD sugar analysis, OBESITY risk factors, OBESITY, MORBID obesity, ADIPOSE tissues, ANALYSIS of covariance, ANTHROPOMETRY, BEHAVIOR modification, BODY weight, CHI-squared test, CHOLESTEROL, CYTOKINES, FASTING, HEALTH behavior, HIGH density lipoproteins, HOMEOSTASIS, LOW density lipoproteins, METABOLISM, NUTRITION, RESEARCH funding, SCHOOL children, LEPTIN, GHRELIN, BODY mass index, HUMAN services programs, CONTROL groups, ACQUISITION of data, PATIENT selection, PHYSICAL activity, DATA analysis software, ADIPONECTIN, WAIST circumference, DIAGNOSIS
Abstract

Background: Overweight in Guadeloupe is a public health matter affecting children and adults. In the present study we evaluated the metabolic profile, including serum ghrelin, leptin and adiponectin levels, in normal weight, overweight and obese school children and we analyzed the potential changes in anthropometric and metabolic risk factors after a 1-year lifestyle intervention program. Methods: Parameters were assessed at baseline and at 1 year. Three groups (G) were defined according the International Obesity Task Force reference values, G1: normal weight / G2: overweight / G3: obese. The lifestyle intervention included dietary counseling, regular physical activity and family support. Results: A total of 120 children (G1: n = 44, G2: n = 39, G3: n = 37), aged 11-15 years and 59 % girls were enrolled. Obese children showed significant lower HDL-C, adiponectin and ghrelin concentrations, higher triglycerides, fasting blood glucose, insulin and leptin levels and also higher frequencies of abdominal obesity (G1: 2.3 %, G2: 28.2 %, G3: 73 %) and insulin resistance (GI: 39 %, G2: 72 %, G3: 89 %) than the other groups. In the overall sample, the linear regressions exploring the associations of ghrelin, adiponectin and leptin with age, gender, BMI z-score, HOMA-IR and tanner stage as independent variables showed strong associations of leptin levels with weight status and insulin resistance at baseline. The models accounted for 58 % of variability in leptin levels compared with 26 and 15 % for adiponectin and ghrelin levels respectively. In 83 children who completed the program, significant decreases in BMI z-score in overweight and obese children were noted. Leptin levels decreased significantly only in the obese group whereas adiponectin concentrations increased significantly in the three groups, In obese children, a significant correlation was found between changes in BMI Z-score, and changes in leptin levels (r = 0.39; P = 0.049) but not with changes in adiponectin levels. Conclusions: Abdominal obesity and insulin resistance were highly prevalent in obese children highlighting their risk of metabolic complications in adulthood. A 1-year long lifestyle intervention was associated with improvement in BMI z-score and metabolic parameters. [ABSTRACT FROM AUTHOR]

Published
2015
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