1. The function of myostatin in the regulation of fat mass in mammals.
- Author
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Bing Deng, Feng Zhang, Jianghui Wen, Shengqiang Ye, Lixia Wang, Yu Yang, Ping Gong, and Siwen Jiang
- Subjects
MAMMAL physiology ,PREVENTION of obesity ,MYOSTATIN ,ADIPOSE tissues ,BODY composition ,CATTLE ,CELL differentiation ,CELLULAR signal transduction ,FAT cells ,GENES ,MICE ,STEM cells ,SKELETAL muscle ,PHYSIOLOGY - Abstract
Myostatin (MSTN), also referred to as growth and differentiation factor-8, is a protein secreted in muscle tissues. Researchers believe that its primary function is in negatively regulating muscle because a mutation in its coding region can lead to the famous double muscle trait in cattle. Muscle and adipose tissue develop from the same mesenchymal stem cells, and researchers have found that MSTN is expressed in fat tissues and plays a key role in adipogenesis. Interestingly, MSTN can exert a dual function, either inhibiting or promoting adipogenesis, according to the situation. Due to its potential function in controlling body fat mass, MSTN has attracted the interest of researchers. In this review, we explore its function in regulating adipogenesis in mammals, including preadipocytes, multipotent stem cells and fat mass. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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