1. Adverse events and adherence to HIV post-exposure prophylaxis: a cohort study at the Korle-Bu Teaching Hospital in Accra, Ghana
- Author
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Tetteh, Raymond A, Nartey, Edmund T, Lartey, Margaret, Mantel-Teeuwisse, Aukje K, Leufkens, Hubert G M, Nortey, Priscilla A, Dodoo, Alexander N O, Sub Gen. Pharmacoepi and Clinical Pharm, Sub Pharmacotherapy, Theoretical, Sub Pharmacoepidemiology, Pharmacoepidemiology and Clinical Pharmacology, Sub Gen. Pharmacoepi and Clinical Pharm, Sub Pharmacotherapy, Theoretical, Sub Pharmacoepidemiology, and Pharmacoepidemiology and Clinical Pharmacology
- Subjects
Adverse event ,Adult ,Male ,medicine.medical_specialty ,Infectious Disease Transmission, Patient-to-Professional ,Anti-HIV Agents ,MedDRA ,medicine.medical_treatment ,Infectious Disease Transmission ,education ,Cohort event monitoring ,Antiretroviral Therapy ,HIV Infections ,Ghana ,Cohort Studies ,Patient-to-Professional ,Zidovudine ,Young Adult ,Acquired immunodeficiency syndrome (AIDS) ,Antiretroviral Therapy, Highly Active ,Internal medicine ,Occupational Exposure ,medicine ,Humans ,Highly Active ,Post-exposure prophylaxis ,Hospitals, Teaching ,Intensive care medicine ,Adverse effect ,business.industry ,Teaching ,Public Health, Environmental and Occupational Health ,Lamivudine ,virus diseases ,Middle Aged ,medicine.disease ,Hospitals ,Regimen ,Drug Combinations ,Adherence ,Female ,business ,Post-Exposure Prophylaxis ,HIV Post-exposure prophylaxis ,Research Article ,Cohort study ,medicine.drug - Abstract
Background There is strong evidence that post-exposure prophylaxis (PEP) with antiretroviral drugs in the timely management of occupational exposures sustained by healthcare workers decreases the risk of HIV infection and PEP is now widely used. Antiretroviral drugs have well documented toxicities and produce adverse events in patients living with HIV/AIDS. In the era of “highly active antiretroviral therapy”, non-adherence to treatment has been closely linked to the occurrence of adverse events in HIV patients and this ultimately influences treatment success but the influence of adverse events on adherence during PEP is less well studied. Methods Following the introduction of a HIV post-exposure prophylaxis program in the Korle-Bu Teaching Hospital in January 2005, the incidence of adverse events and adherence were documented in occupationally-exposed healthcare workers (HCWs) and healthcare students (HCSs). Cohort event monitoring was used in following-up on exposed HCWs/HCSs for the two study outcomes; adverse events and adherence. All adverse events reported were grouped by MedDRA system organ classification and then by preferred term according to prophylaxis regimen. Adherence was determined by the completion of prophylaxis schedule. Cox proportional regression analysis was applied to determine the factors associated with the cohort study outcomes. Differences in frequencies were tested using the Chi square test and p
- Published
- 2015