1. Contributions of CD8 T cells to the pathogenesis of mouse adenovirus type 1 respiratory infection.
- Author
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Molloy CT, Andonian JS, Seltzer HM, Procario MC, Watson ME Jr, and Weinberg JB
- Subjects
- Adenoviridae Infections genetics, Adenoviridae Infections immunology, Adenoviridae Infections virology, Animals, Female, Interferon-gamma genetics, Interferon-gamma immunology, Interleukin-10 genetics, Interleukin-10 immunology, Lung virology, Male, Mastadenovirus genetics, Mastadenovirus isolation & purification, Mice, Mice, Inbred C57BL, Perforin genetics, Perforin immunology, Rodent Diseases genetics, Rodent Diseases virology, Virus Replication, Adenoviridae Infections veterinary, CD8-Positive T-Lymphocytes immunology, Lung immunology, Mastadenovirus physiology, Rodent Diseases immunology
- Abstract
CD8 T cells are key components of the immune response to viruses, but their roles in the pathogenesis of adenovirus respiratory infection have not been characterized. We used mouse adenovirus type 1 (MAV-1) to define CD8 T cell contributions to the pathogenesis of adenovirus respiratory infection. CD8 T cell deficiency in β2m
-/- mice had no effect on peak viral replication in lungs, but clearance of virus was delayed in β2m-/- mice. Virus-induced weight loss and increases in bronchoalveolar lavage fluid total protein, IFN-γ, TNF-α, IL-10, CCL2, and CCL5 concentrations were less in β2m-/- mice than in controls. CD8 T cell depletion had similar effects on virus clearance, weight loss, and inflammation. Deficiency of IFN-γ or perforin had no effect on viral replication or inflammation, but perforin-deficient mice were partially protected from weight loss. CD8 T cells promote MAV-1-induced pulmonary inflammation via a mechanism that is independent of direct antiviral effects., (Copyright © 2017 Elsevier Inc. All rights reserved.)- Published
- 2017
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