1. Colorectal adenomas contain multiple somatic mutations that do not coincide with synchronous adenocarcinoma specimens.
- Author
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Vaqué JP, Martínez N, Varela I, Fernández F, Mayorga M, Derdak S, Beltrán S, Moreno T, Almaraz C, De Las Heras G, Bayés M, Gut I, Crespo J, and Piris MA
- Subjects
- Adenocarcinoma pathology, Adenoma pathology, Aged, Aged, 80 and over, Colorectal Neoplasms pathology, Female, Humans, Male, Adenocarcinoma genetics, Adenoma genetics, Clonal Evolution, Colorectal Neoplasms genetics, Mutation
- Abstract
We have performed a comparative ultrasequencing study of multiple colorectal lesions obtained simultaneously from four patients. Our data show that benign lesions (adenomatous or hyperplastic polyps) contain a high mutational load. Additionally multiple synchronous colorectal lesions show non overlapping mutational signatures highlighting the degree of heterogeneity between multiple specimens in the same patient. Observations in these cases imply that considering not only the number of mutations but an effective oncogenic combination of mutations can determine the malignant progression of colorectal lesions.
- Published
- 2015
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