1. High Frequency of Thyroid Tumor Induction byN-Methyl-N′-nitro-N-nitrosoguanidine in the Hermaphroditic FishRivulus marmoratus
- Author
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Ok-Soon Heo, Eun-Ho Park, Hwa-Hyoung Chang, Hee-Seok Kweon, Kwang-Won Ha, and Kyoung‐Charn Lee
- Subjects
Methylnitronitrosoguanidine ,Cancer Research ,medicine.medical_specialty ,Adenoma ,Biology ,medicine.disease_cause ,Article ,Hermaphrodite ,MNNG ,Internal medicine ,medicine ,Carcinoma ,Animals ,Thyroid Neoplasms ,Carcinogen ,Rivulus marmoratus ,Dose-Response Relationship, Drug ,Epithelioma ,Hermaphroditic fish ,Thyroid ,Fishes ,medicine.disease ,biology.organism_classification ,Molecular biology ,Rivulus ,Endocrinology ,medicine.anatomical_structure ,Oncology ,Thyroid tumor ,Carcinogenesis ,Neoplasm Transplantation - Abstract
In the self-fertilizing hermaphroditic fish, Rivulus marmoratus, the susceptibility to tumor induction by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was evaluated. Seven-day-old fish larvae were exposed for 2 h to MNNG at concentrations ranging from 5 to 25 ppm in a static water bath. The exposed fish were observed at 2 and 4 months after carcinogen treatment to assess tumor development. Within 4 months after 25 ppm MNNG exposure, nearly all fish developed thyroid tumors. The tumor incidences were dose- and time-dependent, and the latent period of tumor induction was less than 2 months. Most induced neoplasms were papillary carcinomas similar histologically to those of rodents and humans, and the tumors were serially transplantable to other fish of the same species. These results demonstrate that rivulus could be useful as a model of thyroid carcinogenesis.
- Published
- 1993
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